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Diethyl fumarate

Name: Diethyl fumarate
Brand: TargetMol
SKU: T40712
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40712Cas No. 623-91-6

Diethyl fumarate, a decomposition product of the pesticide Malathion, causes nonimmune contact urticaria on the skin.

Diethyl fumarate

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Catalog No. T40712Cas No. 623-91-6

Diethyl fumarate, a decomposition product of the pesticide Malathion, causes nonimmune contact urticaria on the skin.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥98%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR

Product Introduction

Diethyl fumarate AI Summary

Diethyl fumarate exhibits both antifungal activity and inhibition of urease enzyme activity. It demonstrates effectiveness against fungi including Candida albicans, Mucor mucedo, and Trichophyton mentagrophytes, with Minimum Inhibitory Concentration (MIC) values reflecting its capacity to inhibit fungal growth. The antifungal effectiveness varies depending on environmental pH and the presence of beef serum, indicating specificity in its activity. Additionally, Diethyl fumarate inhibits Sporosarcina pasteurii CCM 2056 urease, reducing ammonia production from urea substrates. The inhibition is characterised by Ki values ranging from 11,000 nM to 21,700 nM and shows reversible inhibition, with 34.3% enzyme activity recovery at 10 times IC50 concentration after preincubation. These multifaceted bioactivities suggest that Diethyl fumarate might serve as a potential antifungal and urease inhibitor in various biological contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Diethyl fumarate, a decomposition product of the pesticide Malathion, causes nonimmune contact urticaria on the skin.

Chemical Properties

Molecular Weight	172.18
Formula	C₈H₁₂O₄
Cas No.	623-91-6
Smiles	CCOC(=O)\C=C\C(=O)OCC

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 2 mg/mL (11.62 mM), Sonication is recommended.

DMSO: 55 mg/mL (319.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (19.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8079 mL	29.0394 mL	58.0788 mL	290.3938 mL
5 mM	1.1616 mL	5.8079 mL	11.6158 mL	58.0788 mL
10 mM	0.5808 mL	2.9039 mL	5.8079 mL	29.0394 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2904 mL	1.4520 mL	2.9039 mL	14.5197 mL
50 mM	0.1162 mL	0.5808 mL	1.1616 mL	5.8079 mL
100 mM	0.0581 mL	0.2904 mL	0.5808 mL	2.9039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc