FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. The overexpression of FZD6 may play an important role in the development of Colorectal cancer (CRC). FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. FZD6 plays crucial roles in human tumorigenesis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 700.00 | |
1 mg | 5 days | $ 4,570.00 |
Description | FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. The overexpression of FZD6 may play an important role in the development of Colorectal cancer (CRC). FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. FZD6 plays crucial roles in human tumorigenesis. |
Species | Human |
Expression System | HEK293 |
Tag | His |
Accession Number | A0A024R9E9 |
Synonyms | FZ6, frizzled class receptor 6, FZ-6, NDNC10, HFZ6 |
Construction | A DNA sequence encoding the human FZD6 (NP_003497.2) (Met1-Val153) was expressed with a polyhistidine tag at the C-terminus. |
Protein Purity | > 95 % as determined by SDS-PAGE. |
Molecular Weight | 17.1 kDa (predicted) |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. The overexpression of FZD6 may play an important role in the development of Colorectal cancer (CRC). FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. FZD6 plays crucial roles in human tumorigenesis. |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
Frizzled 6 Protein, Human, Recombinant (His) FZ6 FZ 6 frizzled class receptor 6 NDNC 10 HFZ-6 HFZ 6 FZ-6 NDNC10 NDNC-10 HFZ6 recombinant recombinant-proteins proteins protein