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Anti-Alix Antibody (5X926) (Synonyms: Programmed cell death 6-interacting protein, PDCD6IP, PDCD6-interacting ...)

Catalog No. TMAH-00054 Copy Product Info
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Anti-Alix Antibody (5X926) is a Mouse antibody targeting Alix. Anti-Alix Antibody (5X926) can be used in ELISA,WB.

Anti-Alix Antibody (5X926)

Copy Product Info
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Catalog No. TMAH-00054
Synonyms Programmed cell death 6-interacting protein, PDCD6IP, PDCD6-interacting protein, KIAA1375, Hp95, ALIX, ALG-2-interacting protein X, ALG-2-interacting protein 1, AIP1

Anti-Alix Antibody (5X926) is a Mouse antibody targeting Alix. Anti-Alix Antibody (5X926) can be used in ELISA,WB.

Anti-Alix Antibody
(5X926)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2077-10 days7-10 days
100 μL$3487-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-Alix Antibody (5X926) is a Mouse antibody targeting Alix. Anti-Alix Antibody (5X926) can be used in ELISA,WB.
SynonymsProgrammed cell death 6-interacting protein, PDCD6IP, PDCD6-interacting protein, KIAA1375, Hp95, ALIX, ALG-2-interacting protein X, ALG-2-interacting protein 1, AIP1
Ig Type
IgG2b
Clone
5X926
Reactivity
Human
Verified Activity
Western Blot
-Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, U87 whole cell lysate
-All lanes: Alix antibody at 1:1000
-Secondary: Goat polyclonal to mouse IgG at 1/50000 dilution
-Predicted band size: 30, 96 KDa
-Observed band size: 96 KDa
-Exposure time:5min
Application
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted, extracellular exosome. Cell junction, tight junction. Midbody, Midbody ring.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein G purified
AppearanceLiquid
FormulationPreservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
Purity>95%
Research BackgroundMultifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP. By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier. (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human Programmed cell death 6-interacting Protein
Antigen Species
Human
Gene Name
PDCD6IP
Gene ID
Uniprot ID
Biology Area
Others
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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