Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 128.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 622.00 | |
500 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM . |
Targets&IC50 | FEN1 (human):6.8 μM(EC50) |
In vitro | FEN1 inhibition selectively impairs colon cancer cell proliferation in Cdc4 and Mre11a deficiencies, both common in colorectal cancers. FEN1 is a potential chemosensitizer, critical for repairing Methyl methanesulfonate-induced alkylation damage. Knockdown or inhibition increases Temozolomide sensitivity in glioblastoma and colorectal cancer cells.[1] |
Molecular Weight | 284.27 |
Formula | C15H12N2O4 |
CAS No. | 2109805-87-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (175.89 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FEN1-IN-3 2109805-87-8 FEN1 IN 3 FEN1IN3 inhibitor inhibit