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CCX354

Name: CCX354
Brand: TargetMol
SKU: T15253
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15253Cas No. 1010073-75-2

Alias CCX-354, CCX 354, CCR1 antagonist 1

CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.

CCX354

🥰Excellent

Purity: 99.44%

Catalog No. T15253Alias CCX-354, CCX 354, CCR1 antagonist 1Cas No. 1010073-75-2

CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	In Stock	In Stock
5 mg	$591	In Stock	In Stock
10 mg	$957	In Stock	In Stock
25 mg	$1,480	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,500	-	In Stock
200 mg	$3,330	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.44%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.
In vitro	CCX354 displays potent activities in the chemotaxis assay (IC50<100 nM).[1]
In vivo	CCX354 has in vivo anti-inflammatory activity. It also has superior pharmacokinetic properties.[1]
Synonyms	CCX-354, CCX 354, CCR1 antagonist 1

Chemical Properties

Molecular Weight	451.91
Formula	C₂₂H₂₂ClN₇O₂
Cas No.	1010073-75-2
Smiles	COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1nc(-c2ncc[nH]2)c2cccnc12
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (132.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2128 mL	11.0641 mL	22.1283 mL	110.6415 mL
5 mM	0.4426 mL	2.2128 mL	4.4257 mL	22.1283 mL
10 mM	0.2213 mL	1.1064 mL	2.2128 mL	11.0641 mL
20 mM	0.1106 mL	0.5532 mL	1.1064 mL	5.5321 mL
50 mM	0.0443 mL	0.2213 mL	0.4426 mL	2.2128 mL
100 mM	0.0221 mL	0.1106 mL	0.2213 mL	1.1064 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc