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Ligandrol (Synonyms: LGD-4033)

Name: Ligandrol
Brand: TargetMol
SKU: T15750
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T15750 Copy Product Info

Purity: 99.94%

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Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.

Ligandrol

Copy Product Info

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Catalog No. T15750

Synonyms LGD-4033

Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.

Cas No. 1165910-22-4

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Pack Size	Price	USA Stock	Global Stock
25 mg	$39	In Stock	In Stock
50 mg	$59	In Stock	In Stock
100 mg	$88	-	In Stock
200 mg	$129	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.
Targets&IC50	Androgen receptor:Ki: 1 nM
In vitro	Ligandrol (LGD-4033), a novel nonsteroidal oral, selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity.
In vivo	Ligandrol (LGD-4033) has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate In animal models. Ligandrol is well tolerated, has a long elimination half-life and dose-proportional accumulation upon multiple dosing. Ligandrol is safe, has favorable pharmacokinetic profile, and increases lean body mass even during this short period without change in prostate-specific antigen.
Synonyms	LGD-4033

Chemical Properties

Molecular Weight	338.25
Formula	C₁₄H₁₂F₆N₂O
Cas No.	1165910-22-4
Smiles	C1C[C@@H](N(C1)C2=CC(=C(C=C2)C#N)C(F)(F)F)[C@H](C(F)(F)F)O
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (295.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9564 mL	14.7820 mL	29.5639 mL	147.8197 mL
5 mM	0.5913 mL	2.9564 mL	5.9128 mL	29.5639 mL
10 mM	0.2956 mL	1.4782 mL	2.9564 mL	14.7820 mL
20 mM	0.1478 mL	0.7391 mL	1.4782 mL	7.3910 mL
50 mM	0.0591 mL	0.2956 mL	0.5913 mL	2.9564 mL
100 mM	0.0296 mL	0.1478 mL	0.2956 mL	1.4782 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc