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Onartuzumab (MetMAb) is a humanized anti-tyrosine kinase c-MET monovalent monoclonal antibody.Onartuzumab has antitumor activity with inhibitory effects on HGF binding, receptor phosphorylation, and signal transduction.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 450.00 | |
5 mg | In stock | $ 1,860.00 | |
10 mg | In stock | $ 2,490.00 |
Description | Onartuzumab (MetMAb) is a humanized anti-tyrosine kinase c-MET monovalent monoclonal antibody.Onartuzumab has antitumor activity with inhibitory effects on HGF binding, receptor phosphorylation, and signal transduction. |
Targets&IC50 | c-Met:1.8 n M |
In vitro |
Onartuzumab acts specifically by blocking the binding of the HGF α-chain (but not β-chain) to MET[1]. With an inhibitory concentration (IC50) of 1.8 nM, Onartuzumab effectively blocks HGF binding to human c-Met. This inhibition results in the prevention of c-Met auto-phosphorylation and subsequent cell proliferation in numerous cancer cell lines[2]. |
In vivo | Administered twice a week for two months at a dose of 30 mg/kg via intraperitoneal injection, Onartuzumab suppresses tumor growth[3]. |
Synonyms | RG-3638, PRO-14396, MetMAb |
Molecular Weight | N/A |
CAS No. | 1133766-06-9 |
store at low temperature
store at -20°C
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Onartuzumab 1133766-06-9 Tyrosine Kinase/Adaptors c-Met/HGFR RG-3638 PRO-14396 MetMAb inhibitor inhibit