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STAT5-IN-1

Name: STAT5-IN-1
Brand: TargetMol
SKU: T4216
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4216Cas No. 285986-31-4

Alias STAT5 Inhibitor

STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.

STAT5-IN-1

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Purity: 99.92%

Catalog No. T4216Alias STAT5 InhibitorCas No. 285986-31-4

STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$86	In Stock	In Stock
25 mg	$183	In Stock	In Stock
50 mg	$322	In Stock	In Stock
100 mg	$547	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Color:White

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Product Introduction

Bioactivity

Description	STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
Targets&IC50	STAT5:47 μM
In vitro	The chemical compound STAT5-IN-1 serves as an inhibitor of Signal Transducer and Activator of Transcription 5 (STAT5), a protein crucial for cell growth and differentiation. By attaching to the SH2 domain of STAT5, it selectively impedes its activity. While it also affects STAT3, STAT1, and the Lck tyrosine kinase, this inhibition is significantly less pronounced (IC50 > 500 μM). Additionally, STAT5-IN-1 effectively prevents the interaction between STAT5 and DNA within K562 nuclear extracts. Notably, modifying the chromone ring's C6 hydrogen to an ethyl group in STAT5-IN-1 does not diminish its efficacy against STAT5β; however, it eradicates its selectivity towards other STAT family members.
Synonyms	STAT5 Inhibitor

Chemical Properties

Molecular Weight	293.28
Formula	C₁₆H₁₁N₃O₃
Cas No.	285986-31-4
Smiles	O=C(N\N=C\c1coc2ccccc2c1=O)c1cccnc1
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (170.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4097 mL	17.0486 mL	34.0971 mL	170.4855 mL
5 mM	0.6819 mL	3.4097 mL	6.8194 mL	34.0971 mL
10 mM	0.3410 mL	1.7049 mL	3.4097 mL	17.0486 mL
20 mM	0.1705 mL	0.8524 mL	1.7049 mL	8.5243 mL
50 mM	0.0682 mL	0.3410 mL	0.6819 mL	3.4097 mL
100 mM	0.0341 mL	0.1705 mL	0.3410 mL	1.7049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc