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Medifoxamine

Name: Medifoxamine
Brand: TargetMol
SKU: T24444
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24444Cas No. 32359-34-5

Alias Medifoxamina, LG-152, LG152, LG 152

Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake.

Medifoxamine

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Purity: 98.88%

Catalog No. T24444Alias Medifoxamina, LG-152, LG152, LG 152Cas No. 32359-34-5

Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$372	-	In Stock
25 mg	$668	-	In Stock
50 mg	$939	-	In Stock
100 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.88%

Appearance:Liquid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake.
In vivo	Medifoxamine (200, 500, 750, and 1000 mg; oral) was well tolerated and exhibited a first-order linear pharmacokinetic profile. It underwent rapid absorption and peak plasma concentrations were achieved about 1.0 h after administration. Thereafter the elimination profile was biphasic with a mean terminal half-life less than 3 hours. We found a linear relationship (r = 0.80) between administered dose and AUC values for the four doses. High values were obtained for the apparent volumes of distribution and the plasma clearance.[4]
Synonyms	Medifoxamina, LG-152, LG152, LG 152

Chemical Properties

Molecular Weight	257.33
Formula	C₁₆H₁₉NO₂
Cas No.	32359-34-5
Smiles	CN(C)CC(Oc1ccccc1)Oc1ccccc1
Relative Density.	1.076g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (349.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8861 mL	19.4303 mL	38.8606 mL	194.3030 mL
5 mM	0.7772 mL	3.8861 mL	7.7721 mL	38.8606 mL
10 mM	0.3886 mL	1.9430 mL	3.8861 mL	19.4303 mL
20 mM	0.1943 mL	0.9715 mL	1.9430 mL	9.7152 mL
50 mM	0.0777 mL	0.3886 mL	0.7772 mL	3.8861 mL
100 mM	0.0389 mL	0.1943 mL	0.3886 mL	1.9430 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc