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Medifoxamine

Name: Medifoxamine
Brand: TargetMol
SKU: T24444
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24444Cas No. 32359-34-5

Alias Medifoxamina, LG-152, LG152, LG 152

Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake.

Medifoxamine

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Purity: 97.14%

Catalog No. T24444Alias Medifoxamina, LG-152, LG152, LG 152Cas No. 32359-34-5

Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake.

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$372	In Stock
25 mg	$668	In Stock
50 mg	$939	In Stock
100 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.14%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake.
In vivo	Medifoxamine (200, 500, 750, and 1000 mg; oral) was well tolerated and exhibited a first-order linear pharmacokinetic profile. It underwent rapid absorption and peak plasma concentrations were achieved about 1.0 h after administration. Thereafter the elimination profile was biphasic with a mean terminal half-life less than 3 hours. We found a linear relationship (r = 0.80) between administered dose and AUC values for the four doses. High values were obtained for the apparent volumes of distribution and the plasma clearance.[4]
Synonyms	Medifoxamina, LG-152, LG152, LG 152

Chemical Properties

Molecular Weight	257.33
Formula	C₁₆H₁₉NO₂
Cas No.	32359-34-5
Smiles	CN(C)CC(Oc1ccccc1)Oc1ccccc1
Relative Density.	1.076g/cm3
Color	White
Appearance	Liquid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (349.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8861 mL	19.4303 mL	38.8606 mL	194.3030 mL
5 mM	0.7772 mL	3.8861 mL	7.7721 mL	38.8606 mL
10 mM	0.3886 mL	1.9430 mL	3.8861 mL	19.4303 mL
20 mM	0.1943 mL	0.9715 mL	1.9430 mL	9.7152 mL
50 mM	0.0777 mL	0.3886 mL	0.7772 mL	3.8861 mL
100 mM	0.0389 mL	0.1943 mL	0.3886 mL	1.9430 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc