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hDHODH-IN-1

Name: hDHODH-IN-1
Brand: TargetMol
SKU: T11546
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11546Cas No. 1173715-42-8

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibiting anti-inflammatory properties.

hDHODH-IN-1

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Purity: 99.97%

Catalog No. T11546Cas No. 1173715-42-8

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibiting anti-inflammatory properties.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$111	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$323	In Stock	In Stock
100 mg	$449	In Stock	In Stock
200 mg	$606	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibiting anti-inflammatory properties.
In vitro	Human dihydroorotate dehydrogenase (hDHODH), a class-2 dihydroorotate dehydrogenase, is essential for proliferating-cell viability. Consequently, inhibitors targeting hDHODH activity have been developed to address conditions such as cancers, inflammatory diseases, autoimmune disorders, and multiple sclerosis.

Chemical Properties

Molecular Weight	278.31
Formula	C₁₇H₁₄N₂O₂
Cas No.	1173715-42-8
Smiles	C\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1
Relative Density.	1.256 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (179.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5931 mL	17.9656 mL	35.9312 mL	179.6558 mL
5 mM	0.7186 mL	3.5931 mL	7.1862 mL	35.9312 mL
10 mM	0.3593 mL	1.7966 mL	3.5931 mL	17.9656 mL
20 mM	0.1797 mL	0.8983 mL	1.7966 mL	8.9828 mL
50 mM	0.0719 mL	0.3593 mL	0.7186 mL	3.5931 mL
100 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7966 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc