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HQ-415

Name: HQ-415
Brand: TargetMol
SKU: T15502
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T15502Cas No. 430462-93-4

HQ-415, a clinically relevant bioactive metal chelator related to clioquinol, has an effective concentration with an EC50 of 15 μM.

HQ-415

😃Good

Catalog No. T15502Cas No. 430462-93-4

HQ-415, a clinically relevant bioactive metal chelator related to clioquinol, has an effective concentration with an EC50 of 15 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$198	6-8 weeks	6-8 weeks
5 mg	$347	6-8 weeks	6-8 weeks
25 mg	$1,140	6-8 weeks	6-8 weeks
50 mg	$1,490	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$382	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

HQ-415, a clinically relevant bioactive metal chelator related to clioquinol, has an effective concentration with an EC50 of 15 μM.

In vitro

HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 is retested in the dose for their ability to rescue TDP-43. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn. CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity, in TDP-43-expressing cells. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM.

Chemical Properties

Molecular Weight	415.48
Formula	C₂₅H₂₅N₃O₃
Cas No.	430462-93-4
Smiles	CCOc1cc(ccc1OC)C(Nc1cc(C)ccn1)c1ccc2cccnc2c1O
Relative Density.	1.246 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.6 mg/mL (13.48 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4069 mL	12.0343 mL	24.0685 mL	120.3427 mL
5 mM	0.4814 mL	2.4069 mL	4.8137 mL	24.0685 mL
10 mM	0.2407 mL	1.2034 mL	2.4069 mL	12.0343 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HQ-415HQ415HQ 415