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Anti-BRCA1 Monoclonal Antibody (8A852)
(Synonyms: RNF53, PSCP, PPP1R53, PNCA4, IRIS, BROVCA1, BRCC1, BRCAI) Copy Product Info
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Synonyms: RNF53, PSCP, PPP1R53, PNCA4, IRIS, BROVCA1, BRCC1, BRCAI
Catalog No. TMAT-0180 Copy Product Info
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Anti-BRCA1 Monoclonal Antibody (8A852) is a Mouse antibody targeting BRCA1. Anti-BRCA1 Monoclonal Antibody (8A852) can be used in IHC.
Anti-BRCA1 Monoclonal Antibody
(8A852)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-BRCA1 Monoclonal Antibody (8A852) is a Mouse antibody targeting BRCA1. Anti-BRCA1 Monoclonal Antibody (8A852) can be used in IHC. |
| Synonyms | RNF53, PSCP, PPP1R53, PNCA4, IRIS, BROVCA1, BRCC1, BRCAI |
| Ig Type | IgG1 |
| Clone | 8A852 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human BRCA1 (AA: 229-335) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | BRCA1 |
| Gene ID | |
| Protein Name | Breast cancer type 1 susceptibility protein |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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