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Anti-ATXN1 Monoclonal Antibody (6H860)
(Synonyms: SCA1, D6S504E, ATX1) Copy Product Info
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Synonyms: SCA1, D6S504E, ATX1
Catalog No. TMAT-0132 Copy Product Info
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Anti-ATXN1 Monoclonal Antibody (6H860) is a Mouse antibody targeting ATXN1. Anti-ATXN1 Monoclonal Antibody (6H860) can be used in WB,IHC,FCM.
Anti-ATXN1 Monoclonal Antibody
(6H860)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 µL | Inquiry | 7-10 days | 7-10 days | |
| 50 µL | Inquiry | 7-10 days | 7-10 days | |
| 100 µL | Inquiry | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-ATXN1 Monoclonal Antibody (6H860) is a Mouse antibody targeting ATXN1. Anti-ATXN1 Monoclonal Antibody (6H860) can be used in WB,IHC,FCM. |
| Synonyms | SCA1, D6S504E, ATX1 |
| Ig Type | IgG1 |
| Clone | 6H860 |
| Reactivity | Human,Mouse,Rat，Monkey |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/100-1/500; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). Alternative splicing results in multiple transcript variants, with one variant encoding multiple distinct proteins, ATXN1 and Alt-ATXN1, due to the use of overlapping alternate reading frames. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human ATXN1 (AA: 645-815) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | ATXN1 |
| Gene ID | |
| Protein Name | Ataxin-1 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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