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Pregnenolone monosulfate

Name: Pregnenolone monosulfate
Brand: TargetMol
SKU: T12536
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12536Cas No. 1247-64-9

Alias 3β-Hydroxy-5-pregnen-20-one monosulfate

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.

Pregnenolone monosulfate

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Purity: 99.76%

Catalog No. T12536Alias 3β-Hydroxy-5-pregnen-20-one monosulfateCas No. 1247-64-9

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$126	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.
In vitro	Pregnenolone monosulfate, as a signaling-specific negative allosteric modulator, antagonizes most of the known behavioral and in vivo effects of THC. The effect of THC is significantly attenuated when slices are pre-treated with 100 nM Pregnenolone monosulfate (inhibition rate of 15.1±1.8%).
Synonyms	3β-Hydroxy-5-pregnen-20-one monosulfate

Chemical Properties

Molecular Weight	396.54
Formula	C₂₁H₃₂O₅S
Cas No.	1247-64-9
Smiles	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC=C1C[C@@H](OS(=O)(=O)O)CC2)[H])[H]
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (126.09 mM), Sonication is recommended.

H2O: 1.58 mg/mL (3.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5218 mL	12.6091 mL	25.2181 mL	126.0907 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5044 mL	2.5218 mL	5.0436 mL	25.2181 mL
10 mM	0.2522 mL	1.2609 mL	2.5218 mL	12.6091 mL
20 mM	0.1261 mL	0.6305 mL	1.2609 mL	6.3045 mL
50 mM	0.0504 mL	0.2522 mL	0.5044 mL	2.5218 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc