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Pregnenolone monosulfate

Name: Pregnenolone monosulfate
Brand: TargetMol
SKU: T12536
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12536Cas No. 1247-64-9

Alias 3β-Hydroxy-5-pregnen-20-one monosulfate

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.

Pregnenolone monosulfate

🥰Excellent

Purity: 99.46%

Catalog No. T12536Alias 3β-Hydroxy-5-pregnen-20-one monosulfateCas No. 1247-64-9

Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.

Pack Size	Price	Availability
5 mg	$46	In Stock
10 mg	$64	In Stock
25 mg	$126	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Batch Information

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Purity:99.46%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.
In vitro	Pregnenolone monosulfate, as a signaling-specific negative allosteric modulator, antagonizes most of the known behavioral and in vivo effects of THC. The effect of THC is significantly attenuated when slices are pre-treated with 100 nM Pregnenolone monosulfate (inhibition rate of 15.1±1.8%).
Synonyms	3β-Hydroxy-5-pregnen-20-one monosulfate

Chemical Properties

Molecular Weight	396.54
Formula	C₂₁H₃₂O₅S
Cas No.	1247-64-9
Smiles	C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(CC=C1C[C@@H](OS(=O)(=O)O)CC2)[H])[H]
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (126.09 mM), Sonication is recommended.

H2O: 1.58 mg/mL (3.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5218 mL	12.6091 mL	25.2181 mL	126.0907 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5044 mL	2.5218 mL	5.0436 mL	25.2181 mL
10 mM	0.2522 mL	1.2609 mL	2.5218 mL	12.6091 mL
20 mM	0.1261 mL	0.6305 mL	1.2609 mL	6.3045 mL
50 mM	0.0504 mL	0.2522 mL	0.5044 mL	2.5218 mL
100 mM	0.0252 mL	0.1261 mL	0.2522 mL	1.2609 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc