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ICI 118,551 hydrochloride

Name: ICI 118,551 hydrochloride
Brand: TargetMol
SKU: T11607
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11607Cas No. 72795-01-8

Alias ICI 118551 hydrochloride

ICI 118,551 hydrochloride (ICI 118551 hydrochloride) is a highly selective β2 adrenergic receptor antagonist (Kis: 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors).

ICI 118,551 hydrochloride

🥰Excellent

Purity: 99.76%

Catalog No. T11607Alias ICI 118551 hydrochlorideCas No. 72795-01-8

ICI 118,551 hydrochloride (ICI 118551 hydrochloride) is a highly selective β2 adrenergic receptor antagonist (Kis: 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$67	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$156	In Stock	In Stock
100 mg	$229	-	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.76%

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COA LCMS

Product Introduction

Bioactivity

Description	ICI 118,551 hydrochloride (ICI 118551 hydrochloride) is a highly selective β2 adrenergic receptor antagonist (Kis: 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors).
Targets&IC50	β1-adrenoceptor:49.5 nM (ki), β2-adrenoceptor:ki:0.7nM , β3-adrenoceptor:611 nM (ki)
In vitro	ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO [2]. ICI 118551 inhibits cAMP accumulation in IMCD cells (IC50: 1.7 μM) [1]. In the failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances the negative inotropic effects of ICI 118551 [3].
In vivo	ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, strongly reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure in vivo[2].
Synonyms	ICI 118551 hydrochloride

Chemical Properties

Molecular Weight	313.86
Formula	C₁₇H₂₈ClNO₂
Cas No.	72795-01-8
Smiles	Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (63.72 mM), Sonication is recommended.

H2O: 11.11 mg/mL (35.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.37 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1861 mL	15.9307 mL	31.8613 mL	159.3067 mL
5 mM	0.6372 mL	3.1861 mL	6.3723 mL	31.8613 mL
10 mM	0.3186 mL	1.5931 mL	3.1861 mL	15.9307 mL
20 mM	0.1593 mL	0.7965 mL	1.5931 mL	7.9653 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0637 mL	0.3186 mL	0.6372 mL	3.1861 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc