NTRC-824

Name: NTRC-824
Brand: TargetMol
SKU: T16358
Rating: 4.5 (1 reviews)

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Catalog No. T16358Cas No. 1623002-61-8

NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM).

NTRC-824

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Catalog No. T16358Cas No. 1623002-61-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$4,970	35 days	35 days

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Product Introduction

Bioactivity

Description	NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM).
Targets&IC50	NTS2:(ki)202 nM, NTS2:38 nM
In vitro	NTRC-824 is the first nonpeptide compound that behaves like and is more active than, the endogenous ligand. In the NTS1 assay up to 30 μM, Testing of NTRC-824 at the NTS1 receptor displays no binding activity, making NTRC-824 selective for NTS2 in both the binding and functional assays .

Chemical Properties

Molecular Weight	553.55
Formula	C₂₅H₂₆F₃N₃O₆S
Cas No.	1623002-61-8
Smiles	CC(C)C[C@H](NC(=O)Cn1cc(C(=O)C(F)(F)F)c2cc(NS(=O)(=O)c3ccc(C)cc3)ccc12)C(O)=O
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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