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Golidocitinib

Name: Golidocitinib
Brand: TargetMol
SKU: T10431
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10431Cas No. 2091134-68-6

Alias AZD4205

Golidocitinib (AZD4205) is a selective JAK1 inhibitor with an IC50 of 73 nM, while it weakly inhibits JAK2 and JAK3 with IC50 values greater than 14.7 μM and 30 μM, respectively.

Golidocitinib

🥰Excellent

Purity: 99.88%

Catalog No. T10431Alias AZD4205Cas No. 2091134-68-6

Golidocitinib (AZD4205) is a selective JAK1 inhibitor with an IC50 of 73 nM, while it weakly inhibits JAK2 and JAK3 with IC50 values greater than 14.7 μM and 30 μM, respectively.

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$155	In Stock
25 mg	$273	In Stock
50 mg	$425	In Stock
100 mg	$678	In Stock
200 mg	$943	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Purity:99.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Golidocitinib (AZD4205) is a selective JAK1 inhibitor with an IC50 of 73 nM, while it weakly inhibits JAK2 and JAK3 with IC50 values greater than 14.7 μM and 30 μM, respectively.
Targets&IC50	JAK1:73 nM
In vitro	AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50: 161 nM).
In vivo	AZD4205, administered orally at doses of 12.5 mg/kg, 25 mg/kg, or 50 mg/kg twice daily (BID), exhibits dose-dependent antitumor effects when used alone. Additionally, it boosts the antitumor efficacy of osimertinib when compared to the administration of osimertinib alone in mice implanted with NCI-H1975 cells.
Synonyms	AZD4205

Chemical Properties

Molecular Weight	489.57
Formula	C₂₅H₃₁N₉O₂
Cas No.	2091134-68-6
Smiles	COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
Relative Density.	1.38 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (510.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0426 mL	10.2130 mL	20.4261 mL	102.1304 mL
5 mM	0.4085 mL	2.0426 mL	4.0852 mL	20.4261 mL
10 mM	0.2043 mL	1.0213 mL	2.0426 mL	10.2130 mL
20 mM	0.1021 mL	0.5107 mL	1.0213 mL	5.1065 mL
50 mM	0.0409 mL	0.2043 mL	0.4085 mL	2.0426 mL
100 mM	0.0204 mL	0.1021 mL	0.2043 mL	1.0213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc