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Inecalcitol

Name: Inecalcitol
Brand: TargetMol
SKU: T24166
Price: 413 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24166Cas No. 163217-09-2

Alias TX-522, TX522, TX 522

Inecalcitol is a unique vitamin D3 analog that induces apoptosis and has anticancer activity. It is an orally active vitamin D receptor agonist with a Kd of 0.53 nM.

Inecalcitol

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Purity: 99.96%

Catalog No. T24166Alias TX-522, TX522, TX 522Cas No. 163217-09-2

Inecalcitol is a unique vitamin D3 analog that induces apoptosis and has anticancer activity. It is an orally active vitamin D receptor agonist with a Kd of 0.53 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$179	-	In Stock
25 mg	$413	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$128	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.96%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Inecalcitol is a unique vitamin D3 analog that induces apoptosis and has anticancer activity. It is an orally active vitamin D receptor agonist with a Kd of 0.53 nM.
Targets&IC50	Vitamin D3:0.53 nM(Kd)
In vitro	METHODS: SCC cells were treated with Inecalcitol (TX 522) (0.0008, 0.003, 0.012, 0.05, 0.2, 0.8, 3.2, 12.5 nM, 48 hours) and cell viability was measured by MTT assay. RESULTS Inecalcitol inhibited the growth of SCC cells in a dose-dependent manner with an IC50 of 0.38 nM. [1] METHODS: SCC cells were treated with Inecalcitol (TX 522) (1,10 nM), and Western Blot analysis was used to investigate the mechanism of inecalcitol-induced apoptosis. RESULTS Inecalcitol-treated SCC cells resulted in increased activity of caspase 8, 10, and 3, indicating that inecalcitol promotes apoptosis by activating the extrinsic pathway mediated by caspase 8/10 and caspase 3. [1]
In vivo	METHODS: Inecalcitol (TX 522) (1.3 mg/kg, intraperitoneal injection, 3 times a week) was used to treat mice bearing LNCaP cell tumor xenografts. Tumor size was measured and calculated, and blood was collected to measure serum calcium levels. RESULTS Inecalcitol-treated mice bearing tumor xenografts had a significant reduction in tumor size. The half-life of plasma Inecalcitol was 18.3 minutes. [2]
Synonyms	TX-522, TX522, TX 522

Chemical Properties

Molecular Weight	400.59
Formula	C₂₆H₄₀O₃
Cas No.	163217-09-2
Smiles	[H][C@]12CC[C@H]([C@H](C)CC#CC(C)(C)O)[C@@]1(C)CCC\C2=C/C=C1C[C@@H](O)C[C@H](O)C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (137.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4963 mL	12.4816 mL	24.9632 mL	124.8159 mL
5 mM	0.4993 mL	2.4963 mL	4.9926 mL	24.9632 mL
10 mM	0.2496 mL	1.2482 mL	2.4963 mL	12.4816 mL
20 mM	0.1248 mL	0.6241 mL	1.2482 mL	6.2408 mL
50 mM	0.0499 mL	0.2496 mL	0.4993 mL	2.4963 mL
100 mM	0.0250 mL	0.1248 mL	0.2496 mL	1.2482 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc