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Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2
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Catalog No. TMAC-03054
Alias p-PAK2 (Ser141), p-PAK2 (S141), PAK2 (p-Ser141), PAK2 (p-S141)
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody can be used in WB.
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2
😃Good
Catalog No. TMAC-03054Alias p-PAK2 (Ser141), p-PAK2 (S141), PAK2 (p-Ser141), PAK2 (p-S141)
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $218 | 7-10 days | |
| 100 μL | $318 | 7-10 days |
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| Description | Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody can be used in WB. |
| Synonyms | p-PAK2 (Ser141), p-PAK2 (S141), PAK2 (p-Ser141), PAK2 (p-S141) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from HepG2 cells treated with Adriamycin (0.5uM, 24hours) and Jurkat cells treated with PMA (125ng/ml, 30mins) using PAK2 (Phospho-Ser141) antibody TMAC-03054. The lane on the right is treated with the synthesized peptide. |
| Application | |
| Recommended Dose | WB: 1:500-3000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 141 (Y-L-S(p)-F-T) derived from Human PAK2 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 60 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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