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Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2

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Catalog No. TMAC-03054

Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody can be used in WB.

Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2

Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody 2

😃Good
Catalog No. TMAC-03054
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3187-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK2 (Ser141). Anti-Phospho-PAK2 (Ser141) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-3000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundSerine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of serine 141 (Y-L-S(p)-F-T) derived from Human PAK2
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 60 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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