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Ro24-7429

Name: Ro24-7429
Brand: TargetMol
SKU: T28578
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28578Cas No. 139339-45-0

Alias Ro-24-7429, Ro 24-7429, Ro 247429

Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.

Ro24-7429

🥰Excellent

Purity: 99.85%

Catalog No. T28578Alias Ro-24-7429, Ro 24-7429, Ro 247429Cas No. 139339-45-0

Pack Size	Price	Availability
1 mg	$84	In Stock
5 mg	$197	In Stock
10 mg	$313	In Stock
25 mg	$533	In Stock
50 mg	$768	In Stock
100 mg	$1,080	In Stock
500 mg	$3,028	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock

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Purity:99.85%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.
Targets&IC50	C8166 cells:0.7 μM
In vitro	Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[1]. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[2].
In vivo	Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model[1].
Synonyms	Ro-24-7429, Ro 24-7429, Ro 247429

Chemical Properties

Molecular Weight	272.73
Formula	C₁₄H₁₃ClN₄
Cas No.	139339-45-0
Smiles	CNC1=Nc2ccc(Cl)cc2C(=NC1)c1ccc[nH]1
Relative Density.	1.36g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 140 mg/mL (513.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6666 mL	18.3332 mL	36.6663 mL	183.3315 mL
5 mM	0.7333 mL	3.6666 mL	7.3333 mL	36.6663 mL
10 mM	0.3667 mL	1.8333 mL	3.6666 mL	18.3332 mL
20 mM	0.1833 mL	0.9167 mL	1.8333 mL	9.1666 mL
50 mM	0.0733 mL	0.3667 mL	0.7333 mL	3.6666 mL
100 mM	0.0367 mL	0.1833 mL	0.3667 mL	1.8333 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc