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TH-Z835

Catalog No. T78661 CAS 2766209-50-9

TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM. It effectively hampers both mantGMPPNP/GPPNP and GPPNP/mantGMPPNP exchanges [1].

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TH-Z835, CAS 2766209-50-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM. It effectively hampers both mantGMPPNP/GPPNP and GPPNP/mantGMPPNP exchanges [1].
Targets&IC50	KRAS(G12D):1.6 μM
In vitro	TH-Z835 reduces pERK levels in PANC-1 cells with an IC50 value less than 2.5 μM [1]. Additionally, TH-Z835 exhibits antiproliferative effects in various non-G12D mutant cancer cell lines, including 4T1 (KRAS(WT)), MIA PaCa-2 (KRAS(G12C)), CFPAC-1 (KRAS(G12V)), and HCT116 (KRAS(G13D)), by decreasing pERK and pAKT levels and inducing apoptosis, indicating off-target effects [1].
In vivo	TH-Z835 (10mg/kg; intraperitoneal injection) reduces tumor volume in a C57BL/6 mouse model. In vivo, TH-Z835 induces apoptosis and inhibits MAPK signaling [1].

Molecular Weight	498.66
Formula	C30H38N6O
CAS No.	2766209-50-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH-Z835 2766209-50-9 GPCR/G Protein MAPK Ras inhibitor inhibit

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