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JNJ-7777120

Name: JNJ-7777120
Brand: TargetMol
SKU: T2232
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2232Cas No. 459168-41-3

Alias JNJ7777120

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

JNJ-7777120

🥰Excellent

Purity: 99.96%

Catalog No. T2232Alias JNJ7777120Cas No. 459168-41-3

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

Pack Size	Price	Availability
5 mg	$64	In Stock
10 mg	$97	In Stock
25 mg	$173	In Stock
50 mg	$288	In Stock
100 mg	$463	In Stock
500 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock

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Purity:99.96%

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Product Introduction

Bioactivity

Description	JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
Targets&IC50	H4 receptor:4.5 nM(Ki)
In vitro	JNJ 7777120 administration in mice inhibits the migration of tracheal mast cells from connective to epithelial tissues induced by histamine. Furthermore, JNJ 7777120 treatment in mice-derived bone marrow mast cells suppresses histamine-induced chemotaxis and calcium influx. In a peritonitis model induced by yeast polysaccharides in mice, JNJ 7777120 markedly inhibits neutrophil infiltration. The compound demonstrates oral bioavailability, with a 30% rate in rats and 100% in dogs, and a half-life of 3 hours for both species.
In vivo	JNJ 7777120 is an effective, selective antagonist for the H4 receptor, with little to no affinity for over 50 other targets. It binds with high affinity to the H4 receptor, exhibiting over a thousand times greater selectivity compared to other histamine receptors.
Synonyms	JNJ7777120

Chemical Properties

Molecular Weight	277.75
Formula	C₁₄H₁₆ClN₃O
Cas No.	459168-41-3
Smiles	C(=O)(C1=CC=2C(N1)=CC=C(Cl)C2)N3CCN(C)CC3
Relative Density.	1.322g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (144.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6004 mL	18.0018 mL	36.0036 mL	180.0180 mL
5 mM	0.7201 mL	3.6004 mL	7.2007 mL	36.0036 mL
10 mM	0.3600 mL	1.8002 mL	3.6004 mL	18.0018 mL
20 mM	0.1800 mL	0.9001 mL	1.8002 mL	9.0009 mL
50 mM	0.0720 mL	0.3600 mL	0.7201 mL	3.6004 mL
100 mM	0.0360 mL	0.1800 mL	0.3600 mL	1.8002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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