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JNJ-7777120 (Synonyms: JNJ7777120)

Name: JNJ-7777120
Brand: TargetMol
SKU: T2232
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T2232 Copy Product Info

Purity: 99.96%

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JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

JNJ-7777120

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Catalog No. T2232

Synonyms JNJ7777120

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

Cas No. 459168-41-3

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Pack Size	Price	USA Stock	Global Stock
5 mg	$64	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$173	In Stock	In Stock
50 mg	$288	In Stock	In Stock
100 mg	$463	In Stock	In Stock
500 mg	$987	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$67	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
Targets&IC50	H4 receptor:4.5 nM(Ki)
In vitro	JNJ 7777120 administration in mice inhibits the migration of tracheal mast cells from connective to epithelial tissues induced by histamine. Furthermore, JNJ 7777120 treatment in mice-derived bone marrow mast cells suppresses histamine-induced chemotaxis and calcium influx. In a peritonitis model induced by yeast polysaccharides in mice, JNJ 7777120 markedly inhibits neutrophil infiltration. The compound demonstrates oral bioavailability, with a 30% rate in rats and 100% in dogs, and a half-life of 3 hours for both species.
In vivo	JNJ 7777120 is an effective, selective antagonist for the H4 receptor, with little to no affinity for over 50 other targets. It binds with high affinity to the H4 receptor, exhibiting over a thousand times greater selectivity compared to other histamine receptors.
Synonyms	JNJ7777120

Chemical Properties

Molecular Weight	277.75
Formula	C₁₄H₁₆ClN₃O
Cas No.	459168-41-3
Smiles	C(=O)(C1=CC=2C(N1)=CC=C(Cl)C2)N3CCN(C)CC3
Relative Density.	1.322g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (225.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6004 mL	18.0018 mL	36.0036 mL	180.0180 mL
5 mM	0.7201 mL	3.6004 mL	7.2007 mL	36.0036 mL
10 mM	0.3600 mL	1.8002 mL	3.6004 mL	18.0018 mL
20 mM	0.1800 mL	0.9001 mL	1.8002 mL	9.0009 mL
50 mM	0.0720 mL	0.3600 mL	0.7201 mL	3.6004 mL
100 mM	0.0360 mL	0.1800 mL	0.3600 mL	1.8002 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc