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Anti-Keratin 1 Polyclonal Antibody

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Catalog No. TMAB-07983

Anti-Keratin 1 Polyclonal Antibody is a Rabbit antibody targeting Keratin 1. Anti-Keratin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-Keratin 1 Polyclonal Antibody

Anti-Keratin 1 Polyclonal Antibody

😃Good
Catalog No. TMAB-07983
Anti-Keratin 1 Polyclonal Antibody is a Rabbit antibody targeting Keratin 1. Anti-Keratin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Keratin 1 Polyclonal Antibody is a Rabbit antibody targeting Keratin 1. Anti-Keratin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human
Application
IHC-P
IHC-Fr
IF
Recommended Dose
IHC-P: 1:400-800; IHC-Fr: 1:400-800; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells.
Tissue SpecificityThe source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis. Post-translational modifications : Undergoes deimination of some arginine residues (citrullination).
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Keratin 1
Antigen Species
Human
Gene Name
KRT1
Gene ID
3848
Protein Name
Keratin, type II cytoskeletal 1
Uniprot ID
P04264
Function
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK.
Chemical Properties
Molecular WeightTheoretical: 70 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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