Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1]. |
In vitro | NLRP3-IN-16 (Compound 12d) inhibits the release of IL-1β with an IC50 of 0.065 μM, as measured by ELISA [1]. At a concentration of 2 μM, for 3 hours, it suppresses the secretion of IL-1β (p17) and caspase-1 (p20) in mouse peritoneal macrophages (PM) [1]. Additionally, NLRP3-IN-16 impedes the formation of the NLRP3 inflammasome complex by inhibiting ASC oligomerization [1]. It exhibits metabolic stability in human and mouse liver microsomes, with a half-life (T 1/2) of 223.5 minutes and an intrinsic clearance (Cl int) of 6.2 μL/min/mg [1]. |
In vivo | NLRP3-IN-16 (Compound 5j) exhibited anti-inflammatory effects in a sepsis mouse model when administered at a dose of 50 mg/kg intraperitoneally [1]. |
Molecular Weight | 419.47 |
Formula | C25H25NO5 |
CAS No. | 2906872-59-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NLRP3-IN-16 2906872-59-9 Immunology/Inflammation NOD-like Receptor (NLR) inhibitor inhibit