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Anti-TWIST Polyclonal Antibody
(Synonyms: TWST1, Twist-related protein 1, Twist1, TWIST homolog of drosophila, Twist homolog 1(Drosophila), Twist homolog 1, Twist basic helix loop helix transcription factor 1, SCS, OTTHUMP00000116043, H-twist, CRS1, Class A basic helix-loop-helix protein 38, BPES3, BPES2, bHLHa38, B-HLH DNA binding protein, ACS3) Copy Product Info
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Synonyms: TWST1, Twist-related protein 1, Twist1, TWIST homolog of drosophila, Twist homolog 1(Drosophila), Twist homolog 1, Twist basic helix loop helix transcription factor 1, SCS, OTTHUMP00000116043, H-twist, CRS1, Class A basic helix-loop-helix protein 38, BPES3, BPES2, bHLHa38, B-HLH DNA binding protein, ACS3
Catalog No. TMAB-01921 Copy Product Info
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Anti-TWIST Polyclonal Antibody is a Rabbit antibody targeting TWIST. Anti-TWIST Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
Anti-TWIST Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
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| Description | Anti-TWIST Polyclonal Antibody is a Rabbit antibody targeting TWIST. Anti-TWIST Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P. |
| Synonyms | TWST1, Twist-related protein 1, Twist1, TWIST homolog of drosophila, Twist homolog 1(Drosophila), Twist homolog 1, Twist basic helix loop helix transcription factor 1, SCS, OTTHUMP00000116043, H-twist, CRS1, Class A basic helix-loop-helix protein 38, BPES3, BPES2, bHLHa38, B-HLH DNA binding protein, ACS3 |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Subset of mesodermal cells |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human TWIST |
| Antigen Species | Human |
| Gene Name | TWIST1 |
| Gene ID | |
| Protein Name | Twist-related protein 1 |
| Uniprot ID | |
| Biology Area | Transcription factors,Transcription factors/regulators,Mesoderm,Muscle,HLH,Soma marker,Mesoderm |
| Function | Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. |
| Molecular Weight | Theoretical: 23 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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