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ATN-161 acetate
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Catalog No. T10398LCas No. 904763-58-2
Alias ATN-161 acetate(262438-43-7 Free base), ATN161 acetate, Ac-PHSCN-NH2 acetate
ATN-161 acetate, a pentapeptide compound derived from the synergistic region of fibronectin, is a non-competitive integrin-alpha5 antagonist with antitumor activity that attenuates the pathology of caerulein-induced acute pancreatitis.
ATN-161 acetate
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Purity: 98.27%
Catalog No. T10398LAlias ATN-161 acetate(262438-43-7 Free base), ATN161 acetate, Ac-PHSCN-NH2 acetateCas No. 904763-58-2
ATN-161 acetate, a pentapeptide compound derived from the synergistic region of fibronectin, is a non-competitive integrin-alpha5 antagonist with antitumor activity that attenuates the pathology of caerulein-induced acute pancreatitis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 5 mg | $483 | In Stock | In Stock | |
| 10 mg | $692 | In Stock | In Stock | |
| 25 mg | $1,080 | In Stock | In Stock | |
| 50 mg | $1,490 | In Stock | In Stock | |
| 100 mg | $1,970 | - | In Stock | |
| 200 mg | $2,690 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.27%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
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| Description | ATN-161 acetate, a pentapeptide compound derived from the synergistic region of fibronectin, is a non-competitive integrin-alpha5 antagonist with antitumor activity that attenuates the pathology of caerulein-induced acute pancreatitis. |
| In vitro | The treatment regimen of ATN-161 acetate in combination with 5-FU was able to significantly inhibit the proliferation of tumor cells compared to control and monotherapy. In addition, the combination treatment significantly increased the proportion of TUNEL-positive tumor cells, while monotherapy failed to increase TUNEL-positive cells. ATN-161 acetate significantly reduced the number of cancer cells after 48 hours of culture (21% reduction) compared to the control group. [1] ATN-161 acetate prevented vascular endothelial growth factor-induced migration and capillary formation of hCECs, but had no significant effect on proliferation. Starting at 100 nM, ATN-161 acetate decreased the number of cells migrating in response to VEGF in a dose-dependent manner (compared to the VEGF group). [2] |
| In vivo | Injection of ATN-161 acetate after laser photocoagulation reduced choroidal neovascularization (CNV) leakage and neovascularization with an inhibitory effect comparable to that of AF564. [2] |
| Synonyms | ATN-161 acetate(262438-43-7 Free base), ATN161 acetate, Ac-PHSCN-NH2 acetate |
| Molecular Weight | 657.7 |
| Formula | C25H39N9O10S |
| Cas No. | 904763-58-2 |
| Smiles | C(C)(O)=O.C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CS)=O)CO)=O)(=O)[C@H]2N(C(C)=O)CCC2 |
| Relative Density. | no data available |
| Sequence | Ac-Pro-His-Ser-Cys-Asn-NH2.CH3CO2H |
| Sequence Short | PHSCN |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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