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Anti-RET Antibody (8T974)
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Catalog No. TMAC-03578
Alias RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12
Anti-RET Antibody (8T974) is a Rabbit antibody targeting RET. Anti-RET Antibody (8T974) can be used in WB,ICC/IF,IHC,IP,FCM.
Anti-RET Antibody (8T974)
Anti-RET Antibody (8T974)
😃Good
Catalog No. TMAC-03578Alias RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12
Anti-RET Antibody (8T974) is a Rabbit antibody targeting RET. Anti-RET Antibody (8T974) can be used in WB,ICC/IF,IHC,IP,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-RET Antibody (8T974) is a Rabbit antibody targeting RET. Anti-RET Antibody (8T974) can be used in WB,ICC/IF,IHC,IP,FCM. |
| Synonyms | RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12 |
| Ig Type | IgG |
| Clone | 8T974 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of Ret on MCF-7 cells lysates using anti-Ret antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti-Ret antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Ret antibody. Counter stained with hematoxylin. 4. ICC staining Ret in AGS cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Ret in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining Ret in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of SW480 cells with Ret antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicomponent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin. Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung??s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr at position 905 dramatically inhibits Ret autophosphorylation activity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 150/175 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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