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Anti-RET Antibody (8T974) (Synonyms: RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1|...)
Catalog No. TMAC-03578 Copy Product Info
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Anti-RET Antibody (8T974) is a Rabbit antibody targeting RET. Anti-RET Antibody (8T974) can be used in FCM,ICC/IF,IHC,IP,WB.
Anti-RET Antibody (8T974)
Copy Product Info🥰Excellent
Catalog No. TMAC-03578
Synonyms RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12
Anti-RET Antibody (8T974) is a Rabbit antibody targeting RET. Anti-RET Antibody (8T974) can be used in FCM,ICC/IF,IHC,IP,WB.
Anti-RET Antibody
(8T974)
(8T974)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $297 | 7-10 days | 7-10 days | |
| 100 μL | $496 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-RET Antibody (8T974) is a Rabbit antibody targeting RET. Anti-RET Antibody (8T974) can be used in FCM,ICC/IF,IHC,IP,WB. |
| Synonyms | RET-ELE1, RET51, ret proto-oncogene, PTC, MTC1, MEN2B, MEN2A, HSCR1, CDHR16, CDHF12 |
| Ig Type | IgG |
| Clone | 8T974 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of Ret on MCF-7 cells lysates using anti-Ret antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti-Ret antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Ret antibody. Counter stained with hematoxylin. 4. ICC staining Ret in AGS cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Ret in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining Ret in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of SW480 cells with Ret antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.        |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicomponent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin. Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung??s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr at position 905 dramatically inhibits Ret autophosphorylation activity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 150/175 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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