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Biotin-PEG2-NHS ester

Name: Biotin-PEG2-NHS ester
Brand: TargetMol
SKU: T14588
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14588Cas No. 596820-83-6

Biotin-PEG2-NHS ester is a PROTAC linker consisting of biotin, PEG and NHS for the synthesis of PROTAC.

Biotin-PEG2-NHS ester

🥰Excellent

Purity: 99.72%

Catalog No. T14588Cas No. 596820-83-6

Biotin-PEG2-NHS ester is a PROTAC linker consisting of biotin, PEG and NHS for the synthesis of PROTAC.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	-	In Stock
25 mg	$42	-	In Stock
50 mg	$68	-	In Stock
100 mg	$98	-	In Stock
200 mg	$147	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.72%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Biotin-PEG2-NHS ester is a PROTAC linker consisting of biotin, PEG and NHS for the synthesis of PROTAC.
In vitro	PROTACs consist of two distinct ligands linked together: one ligand targets an E3 ubiquitin ligase while the other targets the protein of interest. These compounds utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	500.57
Formula	C₂₁H₃₂N₄O₈S
Cas No.	596820-83-6
Smiles	O=C1NC2CSC(CCCCC(=O)NCCOCCOCCC(=O)ON3C(=O)CCC3=O)C2N1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (199.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9977 mL	9.9886 mL	19.9772 mL	99.8861 mL
5 mM	0.3995 mL	1.9977 mL	3.9954 mL	19.9772 mL
10 mM	0.1998 mL	0.9989 mL	1.9977 mL	9.9886 mL
20 mM	0.0999 mL	0.4994 mL	0.9989 mL	4.9943 mL
50 mM	0.0400 mL	0.1998 mL	0.3995 mL	1.9977 mL
100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.9989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc