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Biotin-PEG2-NHS ester

Name: Biotin-PEG2-NHS ester
Brand: TargetMol
SKU: T14588
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14588Cas No. 596820-83-6

Biotin-PEG2-NHS ester is a PROTAC linker consisting of biotin, PEG and NHS for the synthesis of PROTAC.

Biotin-PEG2-NHS ester

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Purity: 99.72%

Catalog No. T14588Cas No. 596820-83-6

Biotin-PEG2-NHS ester is a PROTAC linker consisting of biotin, PEG and NHS for the synthesis of PROTAC.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$40	-	In Stock
50 mg	$50	-	In Stock
100 mg	$64	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.72%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Biotin-PEG2-NHS ester is a PROTAC linker consisting of biotin, PEG and NHS for the synthesis of PROTAC.
In vitro	PROTACs consist of two distinct ligands linked together: one ligand targets an E3 ubiquitin ligase while the other targets the protein of interest. These compounds utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	500.57
Formula	C₂₁H₃₂N₄O₈S
Cas No.	596820-83-6
Smiles	O=C1NC2CSC(CCCCC(=O)NCCOCCOCCC(=O)ON3C(=O)CCC3=O)C2N1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (199.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9977 mL	9.9886 mL	19.9772 mL	99.8861 mL
5 mM	0.3995 mL	1.9977 mL	3.9954 mL	19.9772 mL
10 mM	0.1998 mL	0.9989 mL	1.9977 mL	9.9886 mL
20 mM	0.0999 mL	0.4994 mL	0.9989 mL	4.9943 mL
50 mM	0.0400 mL	0.1998 mL	0.3995 mL	1.9977 mL
100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.9989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc