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AMDE-1

Name: AMDE-1
Brand: TargetMol
SKU: T23716
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23716Cas No. 478043-30-0

Alias AMDE 1

AMDE-1 is an autophagy modulator and triggers autophagy in an Atg5-dependent manner. AMDE-1 recruits Atg16 to the pre-autophagosomal site and causes LC3 lipidation.

AMDE-1

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Catalog No. T23716Alias AMDE 1Cas No. 478043-30-0

AMDE-1 is an autophagy modulator and triggers autophagy in an Atg5-dependent manner. AMDE-1 recruits Atg16 to the pre-autophagosomal site and causes LC3 lipidation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	-	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$313	-	In Stock
1 mL x 10 mM (in DMSO)	$226	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:Red

Resource Download

COA HNMR

Product Introduction

AMDE-1 AI Summary

AMDE-1 exhibits significant bioactivity in multiple assays, demonstrating its potential as a versatile therapeutic agent. It shows high inhibition percentages (4.0% to 97.0%) against Plasmodium falciparum, the parasite responsible for malaria, with an XC50 value of 726.62 nM in whole erythrocytes. Additionally, AMDE-1 exhibits a 52.0% inhibition rate on the human HepG2 cell line. It also inhibits the Menin-MLL interaction in MLL-related leukemias with a potency of 2511.9 nM and acts as an antagonist of the S1P2 receptor (IC50 of 922.0 nM) and the Neuropeptide S receptor (potency of 10000.0 nM). The compound enhances SMN2 splice variant expression (potency of 1584.9 nM), induces DNA re-replication in normal breast cells (potency of 2310.9 nM), and inhibits Hepatitis C Virus (HCV) with a potency of 2818.4 nM. It also demonstrates activity against TGF-b (potency of 1258.9 nM), has dual-acting properties in a Huntington's disease model (potency of 891.3 nM), and shows cytotoxicity to BJ-TERT-LT-ST RAS-independent fibroblasts (EC50 of 6561.0 nM). Furthermore, AMDE-1 exhibits cytotoxicity against transgenic Leishmania Mexicana promastigotes that are glucose transport deficient, with inhibitory effects ranging from 6.02% to 9.02%. These diverse bioactivities suggest its utility in antileukemic, antiviral, cytotoxic applications, and modulation of various cellular processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AMDE-1 is an autophagy modulator and triggers autophagy in an Atg5-dependent manner. AMDE-1 recruits Atg16 to the pre-autophagosomal site and causes LC3 lipidation.
Synonyms	AMDE 1

Chemical Properties

Molecular Weight	415.72
Formula	C₁₈H₈ClF₆N₃
Cas No.	478043-30-0
Smiles	FC(F)(F)C1=NC2=NC(=CC=C2C(=C1)C(F)(F)F)C(C#N)C1=CC(Cl)=CC=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (132.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4055 mL	12.0273 mL	24.0547 mL	120.2733 mL
5 mM	0.4811 mL	2.4055 mL	4.8109 mL	24.0547 mL
10 mM	0.2405 mL	1.2027 mL	2.4055 mL	12.0273 mL
20 mM	0.1203 mL	0.6014 mL	1.2027 mL	6.0137 mL
50 mM	0.0481 mL	0.2405 mL	0.4811 mL	2.4055 mL
100 mM	0.0241 mL	0.1203 mL	0.2405 mL	1.2027 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc