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Crolibulin

Name: Crolibulin
Brand: TargetMol
SKU: T15012
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15012Cas No. 1000852-17-4

Alias EPC2407

Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.

Crolibulin

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Purity: 98.04%

Catalog No. T15012Alias EPC2407Cas No. 1000852-17-4

Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.

Pack Size	Price	Availability
1 mg	$58	In Stock
2 mg	$84	In Stock
5 mg	$139	In Stock
10 mg	$228	In Stock
25 mg	$396	In Stock
50 mg	$591	In Stock
100 mg	$793	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock

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Batch Information

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Purity:98.04%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.
Targets&IC50	Tubulin polymerization:0.52 μM
In vitro	Crolibulin demonstrates notable cytotoxic effects on HT-29 cells, achieving an IC50 value of 0.52 μM[2]. It is effective against a range of experimental tumors and significantly inhibits mitosis during the G2/M phase[2].
Synonyms	EPC2407

Chemical Properties

Molecular Weight	417.26
Formula	C₁₈H₁₇BrN₄O₃
Cas No.	1000852-17-4
Smiles	COc1cc(cc(Br)c1OC)[C@H]1C(C#N)=C(N)Oc2c(N)c(N)ccc12
Relative Density.	1.62 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (287.59 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3966 mL	11.9829 mL	23.9659 mL	119.8294 mL
5 mM	0.4793 mL	2.3966 mL	4.7932 mL	23.9659 mL
10 mM	0.2397 mL	1.1983 mL	2.3966 mL	11.9829 mL
20 mM	0.1198 mL	0.5991 mL	1.1983 mL	5.9915 mL
50 mM	0.0479 mL	0.2397 mL	0.4793 mL	2.3966 mL
100 mM	0.0240 mL	0.1198 mL	0.2397 mL	1.1983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc