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RIP2 kinase inhibitor 2

Name: RIP2 kinase inhibitor 2
Brand: TargetMol
SKU: T16753
Rating: 4.5 (1 reviews)

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Catalog No. T16753Cas No. 1581270-11-2

RIP2 kinase inhibitor 2 is a compound that inhibits receptor-interacting protein-2 kinase (RIP2).

RIP2 kinase inhibitor 2

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Catalog No. T16753Cas No. 1581270-11-2

RIP2 kinase inhibitor 2 is a compound that inhibits receptor-interacting protein-2 kinase (RIP2).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$196	5 days	5 days
5 mg	$347	5 days	5 days
25 mg	$1,140	8-10 weeks	8-10 weeks
50 mg	$1,490	8-10 weeks	8-10 weeks
100 mg	$1,990	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$328	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	RIP2 kinase inhibitor 2 is a compound that inhibits receptor-interacting protein-2 kinase (RIP2).
In vitro	RIP2 kinase inhibitor 2 is a novel prodrug of a quinazoline amine that inhibits RIP2 kinase, which associates with NODI or NOD2 and functions primarily as a molecular scaffold to assemble other kinases involved in NF-κΒ and mitogen-activated protein kinase activation [1].

Chemical Properties

Molecular Weight	432.54
Formula	C₂₁H₂₈N₄O₄S
Cas No.	1581270-11-2
Smiles	COCCOc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C
Relative Density.	1.266 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (11.56 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3119 mL	11.5596 mL	23.1192 mL	115.5962 mL
5 mM	0.4624 mL	2.3119 mL	4.6238 mL	23.1192 mL
10 mM	0.2312 mL	1.1560 mL	2.3119 mL	11.5596 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc