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Decynium 22

Name: Decynium 22
Brand: TargetMol
SKU: T22714
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22714Cas No. 977-96-8

Decynium 22 is a plasma membrane monoamine transporter (PMAT) inhibitor

Decynium 22

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Purity: 99.98%

Catalog No. T22714Cas No. 977-96-8

Decynium 22 is a plasma membrane monoamine transporter (PMAT) inhibitor

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:Purple to Black

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COA LCMS HNMR

Product Introduction

Decynium 22 AI Summary

Decynium 22 exhibits potent activity in displacing [3H]prazosin from alpha1 adrenoceptors in C57BL/6 mouse hippocampal homogenates at concentrations ranging from 0.0001 µM to 0.01 µM, achieving activity levels between 81.2% and 100.0%. However, at a higher concentration of 30 µM, the compound shows a negative activity of -5.0%. It has an IC50 value of 60.0 nM in this assay. The compound also displays anti-depressant-like effects in mice, reducing immobility time in a tail suspension test following intraperitoneal administration at doses of 1 mg/kg and 3.2 mg/kg. Additionally, Decynium 22 inhibits the Organic Cation Transporter 3 (OCT3, SLC22A3) with an IC50 value of 400.0 nM, as measured by a phenotypic impedance-based assay detecting changes in cell morphology due to MPP+ uptake in HEK-293 JumpIN-SLC22A3 cells. Moreover, it exhibits cytotoxic activity against human HepG2 cells, with an IC50 value of 1000.0 nM as determined by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Decynium 22 is a plasma membrane monoamine transporter (PMAT) inhibitor

Chemical Properties

Molecular Weight	454.35
Formula	C₂₃H₂₃IN₂
Cas No.	977-96-8
Smiles	CCN1/C(=C/C2=[N+](C3=CC=CC=C3C=C2)CC)/C=CC4=CC=CC=C41.[I-]
Relative Density.	1.3883 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (121.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2009 mL	11.0047 mL	22.0095 mL	110.0473 mL
5 mM	0.4402 mL	2.2009 mL	4.4019 mL	22.0095 mL
10 mM	0.2201 mL	1.1005 mL	2.2009 mL	11.0047 mL
20 mM	0.1100 mL	0.5502 mL	1.1005 mL	5.5024 mL
50 mM	0.0440 mL	0.2201 mL	0.4402 mL	2.2009 mL
100 mM	0.0220 mL	0.1100 mL	0.2201 mL	1.1005 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc