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Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody
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Catalog No. TMAB-11232
Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Rb2 p130 (Ser952). Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody can be used in WB.
Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody
Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody
😃Good
Catalog No. TMAB-11232
Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Rb2 p130 (Ser952). Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Rb2 p130 (Ser952). Anti-Phospho-Rb2 p130 (Ser952) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | p130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human Rb2 p130 around the phosphorylation site of Ser952 |
| Antigen Species | Human |
| Gene Name | RBL2 |
| Gene ID | |
| Protein Name | Retinoblastoma-like protein 2 |
| Uniprot ID | |
| Function | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Molecular Weight | Theoretical: 128 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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