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Folitixorin
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Catalog No. T21315Cas No. 3432-99-3
Alias ANX-510 free acid, ANX510 free acid, 5,10-Methylenetetrafolate
Folitixorin (ANX-510) is an active folate derivative and coenzyme associated with thymidine synthesis, with potential antitumour activity.
Folitixorin
😃Good
Purity: 95.94%
Catalog No. T21315Alias ANX-510 free acid, ANX510 free acid, 5,10-MethylenetetrafolateCas No. 3432-99-3
Folitixorin (ANX-510) is an active folate derivative and coenzyme associated with thymidine synthesis, with potential antitumour activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | 6-8 weeks | |
| 5 mg | $804 | In Stock |
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Purity:95.94%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Folitixorin (ANX-510) is an active folate derivative and coenzyme associated with thymidine synthesis, with potential antitumour activity. |
| In vivo | 5-FU (30 mg/kg, intravenous injection) and Folitixorin (15 mg/kg or 30 mg/kg, intravenous injection) were administered intrahepatically to rodents with colon adenocarcinoma cell suspensions. The combination of these two drugs abolished tumor uptake, regardless of folic acid dose. [1] |
| Synonyms | ANX-510 free acid, ANX510 free acid, 5,10-Methylenetetrafolate |
| Molecular Weight | 457.44 |
| Formula | C20H23N7O6 |
| Cas No. | 3432-99-3 |
| Smiles | O=C1C=2N3C(CN(C3)C4=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C4)(CNC2NC(N)=N1)[H] |
| Relative Density. | 1.75 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | The compound is unstable in solution. Please use soon,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (8.74 mM), Sonication is recommended. H2O: 4 mg/mL (8.74 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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