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FGI-106 tetrahydrochloride
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Catalog No. T11281LCas No. 1149348-10-6
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.
FGI-106 tetrahydrochloride
😃Good
Purity: 99.68%
Catalog No. T11281LCas No. 1149348-10-6
FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $79 | In Stock | In Stock | |
| 5 mg | $173 | In Stock | In Stock | |
| 10 mg | $273 | In Stock | In Stock | |
| 25 mg | $452 | In Stock | In Stock | |
| 50 mg | $636 | In Stock | In Stock | |
| 100 mg | $858 | - | In Stock | |
| 200 mg | $1,150 | 10-14 weeks | 10-14 weeks | |
| 1 mL x 10 mM (in DMSO) | $230 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.68%
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Product Introduction
Bioactivity
Chemical Properties
| Description | FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential. |
| Targets&IC50 | HIV-1:150 nM , EBOV:（EC50）100 nM , HCV: 200 nM , Rift Valley virus: 800 nM , DENV: 400-900 nM |
| In vitro | In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM. |
| In vivo | FGI-106??treatment decreases mortality from Zaire EBOV in a dose-dependent manner. |
| Molecular Weight | 604.48 |
| Formula | C28H42Cl4N6 |
| Cas No. | 1149348-10-6 |
| Smiles | Cl.Cl.Cl.Cl.CN(C)CCCNc1cc(C)nc2c1ccc1c2ccc2c(NCCCN(C)C)cc(C)nc12 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/ml (12.41 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
VirusProteaseVirus ProteasetetrahydrochlorideRift Valley virusreplicationpathogenslethalInhibitorinhibitInfluenzaVirusInfluenza VirusHuman immunodeficiency virusHIVProteaseHIV-1HIV ProteaseHIVHepatitis C virushemorrhagicHCVProteaseHCV ProteaseHCVFGI-106 TetrahydrochlorideFGI-106 tetrahydrochlorideFGI106 tetrahydrochlorideFGI106 TetrahydrochlorideFGI-106FGI106FGI 106 tetrahydrochlorideFGI 106 TetrahydrochlorideFGI 106feverEBOVEbola virusEbolaDengue Fever virusbroad-spectrumantiviral
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