Ranbezolid hydrochloride (Synonyms: RBx-7644)

Name: Ranbezolid hydrochloride
Brand: TargetMol
SKU: T213667
Rating: 4.5 (1 reviews)

Catalog No. T213667 Copy Product Info

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Ranbezolid (RBx7644 free base) is an orally effective oxazolidinone antibiotic targeting Gram-positive and Gram-negative anaerobes, such as Staphylococcus aureus, Staphylococcus epidermidis, and Bacteroides fragilis. It inhibits the 50S ribosomal subunit with an IC50 of 17 μM for bacterial ribosomes. Ranbezolid also disrupts cell wall and lipid synthesis. This compound acts rapidly as a bactericidal agent, significantly reducing bacterial load while offering improved cardiovascular safety. Ranbezolid is applicable in research on antibiotics against anaerobic bacteria.

Ranbezolid hydrochloride

Copy Product Info

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Catalog No. T213667

Synonyms RBx-7644

Ranbezolid hydrochloride

Cas No. 392659-39-1

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Ranbezolid (RBx7644 free base) is an orally effective oxazolidinone antibiotic targeting Gram-positive and Gram-negative anaerobes, such as Staphylococcus aureus, Staphylococcus epidermidis, and Bacteroides fragilis. It inhibits the 50S ribosomal subunit with an IC50 of 17 μM for bacterial ribosomes. Ranbezolid also disrupts cell wall and lipid synthesis. This compound acts rapidly as a bactericidal agent, significantly reducing bacterial load while offering improved cardiovascular safety. Ranbezolid is applicable in research on antibiotics against anaerobic bacteria.
In vitro	Ranbezolid at a concentration of 1 μg/mL effectively inhibits protein synthesis in both Staphylococcus aureus and Staphylococcus epidermidis, while also additionally hindering cell wall and lipid synthesis in Staphylococcus epidermidis. At concentrations ranging from 1 to 8 μg/mL, Ranbezolid induces concentration-dependent membrane damage in Staphylococcus epidermidis. The compound exhibits an IC50 of 17 μM against bacterial ribosomes and boasts a safety index of 865. The minimum inhibitory concentrations (MIC) of Ranbezolid for Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Clostridium perfringens, Clostridium difficile, and Clostridium ramosum are 0.06, 0.015, 0.06, 0.06, 0.03, and 0.015 μg/mL, respectively.
In vivo	Ranbezoild (100 mg/kg, p.o., administered twice daily for a total of 5 days) shows excellent in vivo activity against Bacteroides fragilis in a mouse foreign body infection model. Additionally, Ranbezoild (≤ 50 mg/kg, p.o., single dose) does not significantly enhance the pressor response induced by tyramine (Tyramine: HY-W007606) in a spontaneous hypertension rat model.
Synonyms	RBx-7644

Chemical Properties

Molecular Weight	497.91
Formula	C₂₁H₂₅ClFN₅O₆
Cas No.	392659-39-1
Smiles	O=C1N(C[C@H](CNC(C)=O)O1)C2=CC(F)=C(C=C2)N3CCN(CC=4OC(N(=O)=O)=CC4)CC3.Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc