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Tetrahydromagnolol

Name: Tetrahydromagnolol
Brand: TargetMol
SKU: TN2268
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN2268Cas No. 20601-85-8

Tetrahydromagnolol can activate cannabinoid (CB) receptors.

Tetrahydromagnolol

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Purity: 99.99%

Catalog No. TN2268Cas No. 20601-85-8

Tetrahydromagnolol can activate cannabinoid (CB) receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$126	In Stock	In Stock
50 mg	$183	In Stock	In Stock
100 mg	$269	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Tetrahydromagnolol AI Summary

Tetrahydromagnolol is characterized by various bioactivities, including Maxi-K opening activity on cloned human large-conductance Ca(2+)-activated K+ channels expressed in Xenopus laevis oocytes at a concentration of 20 μM, with the control current at 95.9%. The compound also exhibits a pKa value of 9.3 and a high partition coefficient (log P value of 5.76), suggesting it is lipophilic with a likely enhanced ability to cross cell membranes. In terms of cytotoxicity, Tetrahydromagnolol has shown effectiveness against the human liver tumor cell line (Hep-G2) with an IC50 value of 23400.0 nM. It demonstrates notable antagonist activity at the human GPR55 receptor, inhibiting LPI-induced beta-arrestin translocation by 96.0% at 10 μM and with a Kb value of 13300.0 nM. As an agonist, it inhibits forskolin-induced cAMP accumulation at the human CB2 receptor by 49.0% at 10 μM and at the human CB1 receptor by 124.0% at 100 μM relative to CP55,940, showing an EC50 value of 9010.0 nM. Additionally, it functions as a partial agonist at the human CB2 receptor, inhibiting forskolin-induced cAMP accumulation with an EC50 value of 170.0 nM at 100 μM. Further bioactivity includes displacement from human receptors, with a Ki value of 416.0 nM for CB2 and 2260.0 nM for CB1 in displacing [3H]CP55,940. Finally, the compound’s relative potency to manolol at the human CB2 receptor is noted with a ratio of 19.0..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tetrahydromagnolol can activate cannabinoid (CB) receptors.
Targets&IC50	CB2:170 nM (EC50), CB2:416 nM (Ki), CB1:2260 nM (Ki), CB1:9010 nM (EC50)

Chemical Properties

Molecular Weight	270.37
Formula	C₁₈H₂₂O₂
Cas No.	20601-85-8
Smiles	CCCc1ccc(O)c(c1)-c1cc(CCC)ccc1O
Relative Density.	1.080 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (924.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6986 mL	18.4932 mL	36.9864 mL	184.9318 mL
5 mM	0.7397 mL	3.6986 mL	7.3973 mL	36.9864 mL
10 mM	0.3699 mL	1.8493 mL	3.6986 mL	18.4932 mL
20 mM	0.1849 mL	0.9247 mL	1.8493 mL	9.2466 mL
50 mM	0.0740 mL	0.3699 mL	0.7397 mL	3.6986 mL
100 mM	0.0370 mL	0.1849 mL	0.3699 mL	1.8493 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc