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Beraprost sodium

Name: Beraprost sodium
Brand: TargetMol
SKU: T13859
Rating: 4.5 (1 reviews)

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Catalog No. T13859Cas No. 496807-11-5

Beraprost sodium is a stable and orally active prodrug of PGI2.

Beraprost sodium

Copy Product Info

🥰Excellent

Catalog No. T13859Cas No. 496807-11-5

Beraprost sodium is a stable and orally active prodrug of PGI2.

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Product Introduction

Bioactivity

Description	Beraprost sodium is a stable and orally active prodrug of PGI2.
In vitro	Beraprost sodium treatment leads to a significant increase in the number of tube formation, BPS plays an important role on angiogenic activity.
In vivo	Beraprost sodium oral adminstration can mitigate the development of renal interstitial fibrosis, decrease renal oxidative stress through its potential vasodilation effect, and further prevent renal interstitial fibrosis.

Chemical Properties

Molecular Weight	420.481
Formula	C₂₄H₂₉NaO₅
Cas No.	496807-11-5
Smiles	[Na+].CC#CCC(C)[C@@H](O)\C=C\[C@@H]1[C@@H](O)C[C@H]2Oc3c(cccc3CCCC([O-])=O)[C@@H]12
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (594.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3782 mL	11.8911 mL	23.7823 mL	118.9114 mL
5 mM	0.4756 mL	2.3782 mL	4.7565 mL	23.7823 mL
10 mM	0.2378 mL	1.1891 mL	2.3782 mL	11.8911 mL
20 mM	0.1189 mL	0.5946 mL	1.1891 mL	5.9456 mL
50 mM	0.0476 mL	0.2378 mL	0.4756 mL	2.3782 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	1.1891 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc