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O-Phospho-L-serine

Name: O-Phospho-L-serine
Brand: TargetMol
SKU: T1324
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1324Cas No. 407-41-0

Alias Phosphoserine, L-SOP, L-Serine O-phosphate, Dexfosfoserine

O-Phospho-L-serine (Phosphoserine) is the phosphoric acid ester of serine.

O-Phospho-L-serine

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Purity: 99.31%

Catalog No. T1324Alias Phosphoserine, L-SOP, L-Serine O-phosphate, DexfosfoserineCas No. 407-41-0

O-Phospho-L-serine (Phosphoserine) is the phosphoric acid ester of serine.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$31	In Stock	In Stock
500 mg	$70	In Stock	In Stock
1 g	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.31%

Appearance:Solid

Color:White

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Product Introduction

O-Phospho-L-serine AI Summary

O-Phospho-L-serine exhibits a wide range of biological activities across various targets. It acts as an agonist at Metabotropic glutamate receptor 4 (mGluR4) with an EC50 value of 1000.0 nM in mammalian cells as measured by GTPgammaS binding assay and stimulates [3H]phosphatidylinositol accumulation in rat mGluR4 co-expressed with Gqi9 protein in HEK 293 cells, with an EC50 of less than 100000.0 nM. The compound activates several mGlu receptors including mGluR4a, mGluR6, and mGluR7, showing variable potency across rat and human models. Additionally, O-Phospho-L-serine inhibits human recombinant glutamate carboxypeptidase 2 with an IC50 of 523000.0 nM and demonstrates bioactivity against Plasmodium falciparum 3D7 and drug-resistant strains with EC50 values around 1080.0 nM and greater than 1065.0 nM, respectively. It exhibits no cytotoxicity against human hepatocellular carcinoma cell line Huh7 (CC50 > 10000.0 nM) and increases cell viability against Bacillus anthracis lethal toxin-mediated cytotoxicity in mouse RAW264.7 cells by a factor of 2.8 at various concentrations (0.125 to 12.5 uM). O-Phospho-L-serine has anti-viral properties, showing inhibition against SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells and moderate inhibitory activity against SARS-CoV-2 3CL-Pro protease at 20 μM. It also inhibits human cytosolic carbonic anhydrase I with a KA of 0.1 mM and shows variable Ki values for other carbonic anhydrase isoforms. Moreover, O-Phospho-L-serine modulates several enzyme and receptor activities including thyroid hormone receptor-steroid receptor coregulator 2 interaction, human Jumonji domain containing 2E, genomic imprint erasure, TDP1, ALDH1A1, Bacillus subtilis Sfp PPTase, Giardia Lamblia fructose-1,6-bisphosphate aldolase, BLM helicase, cytochrome P450 3A4, GCN5L2, mammalian selenoprotein TrxR1, and Marburg Virus entry into cells. It also shows mixed activity towards cytochrome P450 enzymes and inhibits human HDAC6 by 15.01% using a commercial peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	O-Phospho-L-serine (Phosphoserine) is the phosphoric acid ester of serine.
Synonyms	Phosphoserine, L-SOP, L-Serine O-phosphate, Dexfosfoserine

Chemical Properties

Molecular Weight	185.07
Formula	C₃H₈NO₆P
Cas No.	407-41-0
Smiles	C([C@@H](C(O)=O)N)OP(=O)(O)O
Relative Density.	1.809 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 15 mg/mL (81.05 mM), Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.4034 mL	27.0168 mL	54.0336 mL	270.1680 mL
5 mM	1.0807 mL	5.4034 mL	10.8067 mL	54.0336 mL
10 mM	0.5403 mL	2.7017 mL	5.4034 mL	27.0168 mL
20 mM	0.2702 mL	1.3508 mL	2.7017 mL	13.5084 mL
50 mM	0.1081 mL	0.5403 mL	1.0807 mL	5.4034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc