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ICL-CCIC-0019

Name: ICL-CCIC-0019
Brand: TargetMol
SKU: T27579
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27579Cas No. 936498-64-5

Alias ICL CCIC 0019

ICL-CCIC-0019, an inhibitor of choline kinase alpha (ChoKα), induces G1 arrest, endoplasmic reticulum stress, and apoptosis in cancer cell lines.

ICL-CCIC-0019

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Purity: 99.54%

Catalog No. T27579Alias ICL CCIC 0019Cas No. 936498-64-5

ICL-CCIC-0019, an inhibitor of choline kinase alpha (ChoKα), induces G1 arrest, endoplasmic reticulum stress, and apoptosis in cancer cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$67	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$142	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$382	In Stock	In Stock
200 mg	$562	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

ICL-CCIC-0019 AI Summary

ICL-CCIC-0019 exhibits a diverse range of bioactivities, including antifungal and anticancer properties. It has demonstrated antifungal activity against Cryptococcus neoformans and Candida albicans, with a Minimum Inhibitory Concentration (MIC) of 2800.0 nM for both pathogens. In Cryptococcus neoformans var. grubii H99, it inhibits phospholipase B (PLB1) activity with an inhibition rate of 40.0%. Additionally, ICL-CCIC-0019 shows significant inhibitory effects on choline kinase alpha (CHKA) and growth inhibition of cancer cells. It inhibits CHKA in human HCT116 cells with an EC50 of 1300.0 nM and demonstrates more than 75.0% inhibition at concentrations of 2.4 µM and 6.5 µM. The compound also inhibits the growth of human A549 and HCT116 cells overexpressing CHKA2 with GI50 values of 380.0 nM and 640.0 nM, respectively, and shows inhibition of recombinant delta49N CHKA2 with an IC50 of 270.0 nM. These bioactivities highlight ICL-CCIC-0019's potential in antifungal therapy and cancer treatment by targeting CHKA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ICL-CCIC-0019, an inhibitor of choline kinase alpha (ChoKα), induces G1 arrest, endoplasmic reticulum stress, and apoptosis in cancer cell lines.
Synonyms	ICL CCIC 0019

Chemical Properties

Molecular Weight	572.46
Formula	C₂₆H₄₄Br₂N₄
Cas No.	936498-64-5
Smiles	CN(C1=CC=[N+](CCCCCCCCCCCC[N+]2=CC=C(N(C)C)C=C2)C=C1)C.[Br-].[Br-]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (34.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.49 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7468 mL	8.7342 mL	17.4685 mL	87.3423 mL
5 mM	0.3494 mL	1.7468 mL	3.4937 mL	17.4685 mL
10 mM	0.1747 mL	0.8734 mL	1.7468 mL	8.7342 mL
20 mM	0.0873 mL	0.4367 mL	0.8734 mL	4.3671 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc