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Anti-HVEM Antibody-APC (8R903)

🥰Excellent
Catalog No. TMAY-00635A

Anti-HVEM Antibody-APC (8R903) is a APC-conjugated Rabbit antibody targeting HVEM. Anti-HVEM Antibody-APC (8R903) can be used in FCM.

Anti-HVEM Antibody-APC (8R903)

Anti-HVEM Antibody-APC (8R903)

🥰Excellent
Catalog No. TMAY-00635A
Anti-HVEM Antibody-APC (8R903) is a APC-conjugated Rabbit antibody targeting HVEM. Anti-HVEM Antibody-APC (8R903) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-HVEM Antibody-APC (8R903) is a APC-conjugated Rabbit antibody targeting HVEM. Anti-HVEM Antibody-APC (8R903) can be used in FCM.
Ig Type
Monoclonal Rabbit IgG
Clone
8R903
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human HVEM(CD270) expression on human whole blood lymphocytes. Cells were stained with APC-conjugated anti-Human HVEM(CD270). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Application
FCM
Recommended Dose
5 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human HVEM/TNFRSF14/CD270 (rh HVEM/TNFRSF14/CD270; TMPY-01750; NP_003811.2; Met1-Val202) and conjugated with APC under optimum conditions, the unreacted APC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.09% sodium azide
Research BackgroundHerpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
APC
Others Formats
Unconjugated/FITC/PE
Antibody Types Available
4
Antigen Details
Immunogen
Recombinant Human HVEM/TNFRSF14/CD270 Protein (TMPY-01750)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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