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Diflorasone Diacetate

Name: Diflorasone Diacetate
Brand: TargetMol
SKU: T21192
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Purity: 99.47%

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Diflorasone diacetate is a topical anti-inflammatory steroid preparation used in dermatological research to alleviate corticosteroid-responsive skin diseases.

Cas No. 33564-31-7

Pack Size	Price	USA Stock	Global Stock
5 mg	$40	-	In Stock
10 mg	$64	-	In Stock
25 mg	$129	-	In Stock
50 mg	$213	-	In Stock
100 mg	$328	-	In Stock
1 mL x 10 mM (in DMSO)	$43	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.47%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

Diflorasone diacetate is a topical anti-inflammatory steroid preparation used in dermatological research to alleviate corticosteroid-responsive skin diseases.

In vivo

Method: Allergic contact dermatitis was induced in BALB/c mice by topical application of dinitrochlorobenzene (DNCB) or toluene-2,4-diisocyanate (TDI). Diflorasone diacetate (0.05%, 10 μg/20 μL) was applied locally to the right ear 2 hours before challenge. Ear thickness, inflammatory cell infiltration, and chemokine (RANTES, TARC, CTACK) concentrations in ear tissue homogenates were measured 24 hours after challenge using ELISA. Infiltration of CD4⁺ T cells, CD8⁺ T cells, and neutrophils was assessed by immunohistochemistry.
Result: Topical pretreatment with Diflorasone diacetate significantly inhibited TDI- and DNCB-induced ear swelling (P < 0.05) and markedly reduced the infiltration of CD4⁺, CD8⁺ T cells, and GR-1⁺ neutrophils at the inflamed site [16]. It significantly reduced elevated RANTES levels in both models. In the DNCB model, it suppressed the increase in TARC, whereas in the TDI model, it paradoxically led to a significant increase in TARC concentration (P < 0.05). No significant effect on CTACK levels was observed [1].

Chemical Properties

Molecular Weight	494.53
Formula	C₂₆H₃₂F₂O₇
Cas No.	33564-31-7
Smiles	C(COC(C)=O)(=O)[C@]1(OC(C)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](F)([C@@H](O)C2)[C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)[H])[H]
Relative Density.	1.2001 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (161.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0221 mL	10.1106 mL	20.2212 mL	101.1061 mL
5 mM	0.4044 mL	2.0221 mL	4.0442 mL	20.2212 mL
10 mM	0.2022 mL	1.0111 mL	2.0221 mL	10.1106 mL
20 mM	0.1011 mL	0.5055 mL	1.0111 mL	5.0553 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0221 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PsorconMaxiflorFlorone EDiflorasone DiacetateDiflorasoneApexicon E

Related Tags: Diflorasone Diacetate chemical structure | Diflorasone Diacetate in vivo | Diflorasone Diacetate formula | Diflorasone Diacetate molecular weight