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4-(Dimethylamino)-1-methylpyridinium (iodide)

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Catalog No. T36867Cas No. 7538-79-6

4-(Dimethylamino)-1-methylpyridinium is a monoquaternary pyridinium salt with anticholinesterase and antiproliferative activities. It inhibits cholinesterase activity in rat brain homogenates with a Kd value of 33 μM and yeast choline kinase (ChoK) with an IC50 value of 17 μM. 4-(Dimethylamino)-1-methylpyridinium also has antiproliferative activity against HT-29 colon cancer cells (IC50 = 2 μM).

4-(Dimethylamino)-1-methylpyridinium (iodide)

4-(Dimethylamino)-1-methylpyridinium (iodide)

😃Good
Catalog No. T36867Cas No. 7538-79-6
4-(Dimethylamino)-1-methylpyridinium is a monoquaternary pyridinium salt with anticholinesterase and antiproliferative activities. It inhibits cholinesterase activity in rat brain homogenates with a Kd value of 33 μM and yeast choline kinase (ChoK) with an IC50 value of 17 μM. 4-(Dimethylamino)-1-methylpyridinium also has antiproliferative activity against HT-29 colon cancer cells (IC50 = 2 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$11335 days35 days
50 mg$49335 days35 days
100 mg$86235 days35 days
250 mg$1,92035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
4-(Dimethylamino)-1-methylpyridinium is a monoquaternary pyridinium salt with anticholinesterase and antiproliferative activities. It inhibits cholinesterase activity in rat brain homogenates with a Kd value of 33 μM and yeast choline kinase (ChoK) with an IC50 value of 17 μM. 4-(Dimethylamino)-1-methylpyridinium also has antiproliferative activity against HT-29 colon cancer cells (IC50 = 2 μM).
Chemical Properties
Molecular Weight264.11
FormulaC8H13IN2
Cas No.7538-79-6
Smiles[I-].C=1C=[N+](C=CC1N(C)C)C
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
PBS (pH 7.2): 10 mg/mL (37.86 mM), Sonication is recommended.
DMF: 20 mg/mL (75.73 mM), Sonication is recommended.
Ethanol: 5 mg/mL (18.93 mM), Sonication is recommended.
DMSO: 10 mg/mL (37.86 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
1 mM3.7863 mL18.9315 mL37.8630 mL189.3151 mL
5 mM0.7573 mL3.7863 mL7.5726 mL37.8630 mL
10 mM0.3786 mL1.8932 mL3.7863 mL18.9315 mL
PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
20 mM0.1893 mL0.9466 mL1.8932 mL9.4658 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

4(Dimethylamino)1methylpyridinium (iodide)4-(Dimethylamino)-1-methylpyridinium4 (Dimethylamino) 1 methylpyridinium (iodide)
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