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Anti-Dishevelled 3 Polyclonal Antibody

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Catalog No. TMAB-05173

Anti-Dishevelled 3 Polyclonal Antibody is a Rabbit antibody targeting Dishevelled 3. Anti-Dishevelled 3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.

Anti-Dishevelled 3 Polyclonal Antibody

Anti-Dishevelled 3 Polyclonal Antibody

😃Good
Catalog No. TMAB-05173
Anti-Dishevelled 3 Polyclonal Antibody is a Rabbit antibody targeting Dishevelled 3. Anti-Dishevelled 3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5287-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Dishevelled 3 Polyclonal Antibody is a Rabbit antibody targeting Dishevelled 3. Anti-Dishevelled 3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Rat (predicted:Human,Mouse,Chicken,Dog,Pig,Cow,Sheep)
Application
IHC-P
IHC-Fr
IF
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundMammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Dishevelled 3/DVL3
Antigen Species
Human
Gene Name
DVL3
Gene ID
1857
Protein Name
Segment polarity protein dishevelled homolog DVL-3
Uniprot ID
Q92997
Function
May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Chemical Properties
Molecular WeightTheoretical: 78 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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