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Anti-Dishevelled 3 Polyclonal Antibody
Catalog No. TMAB-05173 Copy Product Info
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Anti-Dishevelled 3 Polyclonal Antibody is a Rabbit antibody targeting Dishevelled 3. Anti-Dishevelled 3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Dishevelled 3 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-05173
Anti-Dishevelled 3 Polyclonal Antibody is a Rabbit antibody targeting Dishevelled 3. Anti-Dishevelled 3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Dishevelled 3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Dishevelled 3 Polyclonal Antibody is a Rabbit antibody targeting Dishevelled 3. Anti-Dishevelled 3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Chicken,Dog,Pig,Cow,Sheep) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Dishevelled 3) Polyclonal Antibody, Unconjugated (TMAB-05173) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway. |
| Immunogen | KLH conjugated synthetic peptide: human Dishevelled 3/DVL3 |
| Antigen Species | Human |
| Gene Name | DVL3 |
| Gene ID | |
| Protein Name | Segment polarity protein dishevelled homolog DVL-3 |
| Uniprot ID | |
| Function | May play a role in the signal transduction pathway mediated by multiple Wnt genes. |
| Molecular Weight | Theoretical: 78 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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