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Anti-Torsin B Polyclonal Antibody

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Catalog No. TMAB-13685

Anti-Torsin B Polyclonal Antibody is a Rabbit antibody targeting Torsin B. Anti-Torsin B Polyclonal Antibody can be used in WB.

Anti-Torsin B Polyclonal Antibody

Anti-Torsin B Polyclonal Antibody

😃Good
Catalog No. TMAB-13685
Anti-Torsin B Polyclonal Antibody is a Rabbit antibody targeting Torsin B. Anti-Torsin B Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Torsin B Polyclonal Antibody is a Rabbit antibody targeting Torsin B. Anti-Torsin B Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Dog,Cow,Horse,Sheep)
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationEndoplasmic reticulum and nuclear envelope
Tissue SpecificityWidely expressed with low levels in brain. Not detected in fetal brain.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundTorsinB is a 336 amino acid protein that localizes to the lumen of endoplasmic reticulum and belongs to the Torsin family. Expressed in a variety of tissues with particularly high levels in adult brain, TorsinB is thought to function as a molecular chaperone that assists in the conformational folding of membrane and secreted proteins. Via its ability to regulate protein folding, TorsinB plays a key role in postnatal developmental events and is essential for proper neurological development. TorsinB contains two PKC (protein kinase C) phosphorylations sites, one ATP binding domain and several conserved cysteines and shares 69% amino acid identity with TorsinA, a related family member. Defects in the gene encoding TorsinB are associated with torsion dystonia, an autosomal dominant neurological disorder that is characterized by debilitating muscle contractions throughout the body.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Torsin B
Antigen Species
Human
Gene Name
TOR1B
Gene ID
Protein Name
Torsin-1B
Uniprot ID
Function
Torsins are members of the AAA(+) superfamily of ATPases and are present in all multicellular organisms. Torsin B is an ER protein involved implicated in neurogenesis, neuronal migration, axon/dendrite development and synaptogenesis.
Chemical Properties
Molecular WeightTheoretical: 36 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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