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Crenulatin
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Catalog No. TN1532Cas No. 63026-02-8
Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity.
Crenulatin
🥰Excellent
Purity: 99.86%
Catalog No. TN1532Cas No. 63026-02-8
Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 5 mg | $179 | In Stock | |
| 10 mg | $297 | In Stock | |
| 25 mg | $499 | In Stock |
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Purity:99.86%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity. |
| In vitro | In mouse cerebral microvascular endothelial cells (bEnd.3), Crenulatin showed dose-dependent bidirectional effects on apoptosis after 24 hours of treatment. At 25 mg/L, Crenulatin inhibited apoptosis (with decreased Fas and caspase-3 expression and increased Bcl-2 expression). At 100 mg/L, Crenulatin promoted apoptosis (with increased Fas and caspase-3 expression and decreased Bcl-2 expression)[1]. |
| Molecular Weight | 248.27 |
| Formula | C11H20O6 |
| Cas No. | 63026-02-8 |
| Smiles | O(C(C=C)(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |
| Relative Density. | 1.28 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (322.23 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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