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Crenulatin

Name: Crenulatin
Brand: TargetMol
SKU: TN1532
Price: 86 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1532Cas No. 63026-02-8

Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity.

Crenulatin

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Purity: 99.86%

Catalog No. TN1532Cas No. 63026-02-8

Pack Size	Price	Availability
1 mg	$86	In Stock
5 mg	$207	In Stock
10 mg	$306	In Stock
25 mg	$516	In Stock

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Batch Information

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Purity:99.86%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

In mouse cerebral microvascular endothelial cells (bEnd.3), Crenulatin showed dose-dependent bidirectional effects on apoptosis after 24 hours of treatment. At 25 mg/L, Crenulatin inhibited apoptosis (with decreased Fas and caspase-3 expression and increased Bcl-2 expression). At 100 mg/L, Crenulatin promoted apoptosis (with increased Fas and caspase-3 expression and decreased Bcl-2 expression)[1].

Chemical Properties

Molecular Weight	248.27
Formula	C₁₁H₂₀O₆
Cas No.	63026-02-8
Smiles	O(C(C=C)(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (322.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0279 mL	20.1394 mL	40.2787 mL	201.3936 mL
5 mM	0.8056 mL	4.0279 mL	8.0557 mL	40.2787 mL
10 mM	0.4028 mL	2.0139 mL	4.0279 mL	20.1394 mL
20 mM	0.2014 mL	1.0070 mL	2.0139 mL	10.0697 mL
50 mM	0.0806 mL	0.4028 mL	0.8056 mL	4.0279 mL
100 mM	0.0403 mL	0.2014 mL	0.4028 mL	2.0139 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc