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Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $91 | In Stock | |
5 mg | $218 | In Stock | |
10 mg | $322 | In Stock | |
25 mg | $543 | In Stock |
Description | Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity. |
In vitro | In mouse cerebral microvascular endothelial cells (bEnd.3), Crenulatin showed dose-dependent bidirectional effects on apoptosis after 24 hours of treatment. At 25 mg/L, Crenulatin inhibited apoptosis (with decreased Fas and caspase-3 expression and increased Bcl-2 expression). At 100 mg/L, Crenulatin promoted apoptosis (with increased Fas and caspase-3 expression and decreased Bcl-2 expression)[1]. |
Molecular Weight | 248.27 |
Formula | C11H20O6 |
Cas No. | 63026-02-8 |
Smiles | O(C(C=C)(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |
Relative Density. | 1.28 g/cm3 (Predicted) |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80.00 mg/mL (322.23 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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