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Crenulatin

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Catalog No. TN1532Cas No. 63026-02-8

Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity.

Crenulatin

Crenulatin

🥰Excellent
Purity: 99.86%
Catalog No. TN1532Cas No. 63026-02-8
Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity.
Pack SizePriceAvailabilityQuantity
1 mg$91 In Stock
5 mg$218 In Stock
10 mg$322 In Stock
25 mg$543 In Stock
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Purity:99.86%
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Product Introduction

Bioactivity
Description
Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas/Bcl-2 expression and caspase-3 activity.
In vitro
In mouse cerebral microvascular endothelial cells (bEnd.3), Crenulatin showed dose-dependent bidirectional effects on apoptosis after 24 hours of treatment. At 25 mg/L, Crenulatin inhibited apoptosis (with decreased Fas and caspase-3 expression and increased Bcl-2 expression). At 100 mg/L, Crenulatin promoted apoptosis (with increased Fas and caspase-3 expression and decreased Bcl-2 expression)[1].
Chemical Properties
Molecular Weight248.27
FormulaC11H20O6
Cas No.63026-02-8
SmilesO(C(C=C)(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.1.28 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (322.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0279 mL20.1394 mL40.2787 mL201.3936 mL
5 mM0.8056 mL4.0279 mL8.0557 mL40.2787 mL
10 mM0.4028 mL2.0139 mL4.0279 mL20.1394 mL
20 mM0.2014 mL1.0070 mL2.0139 mL10.0697 mL
50 mM0.0806 mL0.4028 mL0.8056 mL4.0279 mL
100 mM0.0403 mL0.2014 mL0.4028 mL2.0139 mL

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