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Anti-Gremlin-1 Antibody (8R57)

🥰Excellent
Catalog No. TMAY-03032

Anti-Gremlin-1 Antibody (8R57) is a Rabbit antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (8R57) can be used in ELISA.

Anti-Gremlin-1 Antibody (8R57)

Anti-Gremlin-1 Antibody (8R57)

🥰Excellent
Catalog No. TMAY-03032
Anti-Gremlin-1 Antibody (8R57) is a Rabbit antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (8R57) can be used in ELISA.
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Product Introduction

Bioactivity
Description
Anti-Gremlin-1 Antibody (8R57) is a Rabbit antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (8R57) can be used in ELISA.
Ig Type
Monoclonal Rabbit IgG
Clone
8R57
Reactivity
Mouse
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse GREM1 (O70326Met1-Asp184).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundGREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by Grem 1 of BMPs in mice allows the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (Shh) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as an inhibitor of monocyte chemotaxis. GREM1 is highly expressed in the small intestine, fetal brain, and colon.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Mouse GREM1 protein
Antigen Species
Mouse
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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