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Anti-DEP-1 Antibody (1M971)
🥰Excellent
Catalog No. TMAY-02515
Anti-DEP-1 Antibody (1M971) is a Mouse antibody targeting DEP-1. Anti-DEP-1 Antibody (1M971) can be used in ELISA.
Anti-DEP-1 Antibody (1M971)
Anti-DEP-1 Antibody (1M971)
🥰Excellent
Catalog No. TMAY-02515
Anti-DEP-1 Antibody (1M971) is a Mouse antibody targeting DEP-1. Anti-DEP-1 Antibody (1M971) can be used in ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-DEP-1 Antibody (1M971) is a Mouse antibody targeting DEP-1. Anti-DEP-1 Antibody (1M971) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1M971 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DEP1 / PTPRJ (rh DEP1 / PTPRJ; TMPY-02763; Q12913; Arg997-Ala1337). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. DEP1 / PTPRJ is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. In stable MCF-7 cell lines, induction of DEP-1 expression inhibited breast cancer cell growth by 5-10-fold. These data describe PTPs expressed and regulated in breast cancer cell lines during differentiation and identify one PTP, DEP-1, that inhibits the growth of breast cancer cells in vitro. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human DEP1 / PTPRJ Protein (TMPY-02763) |
| Antigen Species | Human |
| Biology Area | Phosphatases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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