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BRD 9757

🥰Excellent
Catalog No. T25175Cas No. 1423058-85-8
Alias N-Hydroxy-1-cyclopentene-1-carboxamide, BRD-9757, BRD9757

BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).

BRD 9757

BRD 9757

🥰Excellent
Purity: 100%
Catalog No. T25175Alias N-Hydroxy-1-cyclopentene-1-carboxamide, BRD-9757, BRD9757Cas No. 1423058-85-8
BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).
Pack SizePriceAvailabilityQuantity
1 mg$35In Stock
5 mg$81In Stock
10 mg$123In Stock
25 mg$239In Stock
50 mg$359In Stock
100 mg$539In Stock
500 mg$1,150In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:100%
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Product Introduction

Bioactivity
Description
BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).
Targets&IC50
HDAC1:0.638 μM, HDAC4:21.80 μM, HDAC9:>33.33 μM, HDAC3:0.694 μM, HDAC8:1.09 μM, HDAC6:0.03 μM, HDAC7:12.61 μM, HDAC2:1.79 μM, HDAC5:18.32 μM
In vitro
The IC50s are 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM and >33.33 μM, respectively for HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8 and HDAC9. BRD 9757 (10-30 μM) selectively increases Ac-tubulin levels without affecting histone acetylation[1].
AliasN-Hydroxy-1-cyclopentene-1-carboxamide, BRD-9757, BRD9757
Chemical Properties
Molecular Weight127.14
FormulaC6H9NO2
Cas No.1423058-85-8
SmilesC(NO)(=O)C=1CCCC1
Relative Density.1.257 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1.27 mg/mL (10 mM, insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM7.8653 mL39.3267 mL78.6535 mL393.2673 mL
5 mM1.5731 mL7.8653 mL15.7307 mL78.6535 mL
10 mM0.7865 mL3.9327 mL7.8653 mL39.3267 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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