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Pomalidomide-PEG1-CO2H

Name: Pomalidomide-PEG1-CO2H
Brand: TargetMol
SKU: T40024
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40024Cas No. 2139348-60-8

Alias Pomalidomide-PEG1-C2-COOH

Pomalidomide-PEG1-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.

Pomalidomide-PEG1-CO2H

🥰Excellent

Purity: 97.24%

Catalog No. T40024Alias Pomalidomide-PEG1-C2-COOHCas No. 2139348-60-8

Pomalidomide-PEG1-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$64	In Stock
25 mg	$122	In Stock
50 mg	$172	In Stock
100 mg	$255	In Stock
500 mg	$628	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.24%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Pomalidomide-PEG1-CO2H is a synthetic E3 ligase ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a 2-unit PEG linker.
In vitro	PROTACs contain two distinct ligands, one for the E3 ubiquitin ligase and the other for the target protein, linked by a linker[1].
Synonyms	Pomalidomide-PEG1-C2-COOH

Chemical Properties

Molecular Weight	389.36
Formula	C₁₈H₁₉N₃O₇
Cas No.	2139348-60-8
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCC(O)=O
Relative Density.	1.508 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (256.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.27 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5683 mL	12.8416 mL	25.6832 mL	128.4159 mL
5 mM	0.5137 mL	2.5683 mL	5.1366 mL	25.6832 mL
10 mM	0.2568 mL	1.2842 mL	2.5683 mL	12.8416 mL
20 mM	0.1284 mL	0.6421 mL	1.2842 mL	6.4208 mL
50 mM	0.0514 mL	0.2568 mL	0.5137 mL	2.5683 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2842 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc